IL-12RB1 Protein, Human, Recombinant

IL-12RB1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 57.11 kDa and the accession number is NP_005526.1.

生物活性	Immobilized Recombinant Human IL12RB1 Protein(ECD) at 2μg/mL (100μL/well) can bind Recombinant Human IL12B / P40 Protein (Fc Tag) , the EC50 is 90-270 ng/mL.
产品描述	IL-12RB1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 57.11 kDa and the accession number is NP_005526.1.

种属	Human
表达系统	HEK293 Cells
标签	Tag Free
蛋白编号	NP_005526.1
别名	CD212, IMD30, interleukin 12 receptor, beta 1, IL-12R-β1, IL12RB, interleukin 12 receptor, β1, IL-12R-BETA1
蛋白构建	Human IL12RB1 (NP_005526.1) (Met1-Glu540)
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	57.11 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. 0.5 mM EDTA. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 (IL12) with a low affinity and is thought to be a part of the IL12 receptor complex. IL12RB1(CD212) forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of IL12RB1 and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. IL12RB1(CD212) Functions as an interleukin receptor that binds interleukin-12 with low affinity and is involved in IL12 transduction. It is associated with IL12RB2 it forms a functional, high-affinity receptor for IL12. IL12RB1(CD212) associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.