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Ximoprofen

产品编号 T35180 CAS 56187-89-4

别名: Ximoprofeno, Ximoprofenum

Ximoprofen 是一种新型抗炎化合物，可用于研究脊柱炎。

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Ximoprofen, CAS 56187-89-4

规格	价格/CNY	货期
1 mg	￥ 2,620	现货
5 mg	￥ 6,270	现货
10 mg	￥ 8,580	现货
25 mg	￥ 12,700	现货
50 mg	￥ 17,200	现货
100 mg	￥ 23,200	现货

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选择批次

纯度: 98.27%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

Ximoprofen is a novel anti-inflammatory compound for the study of spondylitis.

体内活性

The aim of the study was to evaluate the efficacy of different daily dosages of Ximoprofen in patients with active ankylosing spondylitis. For 2 weeks 5 parallel groups were studied: placebo and Ximoprofen at 5, 10, 20, and 30 mg daily. Response to treatment was defined as an improvement in pain (VAS 100 mm) of at least 50% during the study. At the end of the study, the percentage of responders was higher in the Ximoprofen groups (54%, 41%, 53%, 56% in the 5, 10, 20, and 30 mg groups, respectively) than in the placebo group (21%). The clearest dose-related effect of Ximoprofen observed occurred after one week of treatment. This study 1/confirms the efficacy of Ximoprofen at a 30 mg daily dosage, 2/shows the persistence of this efficacy at lower dosages, 3/suggests that ankylosing spondylitis is a sensitive and relevant human model to assess NSAIDs at an early stage of clinical evaluation.[1]

别名	Ximoprofeno, Ximoprofenum
分子量	261.32
分子式	C15H19NO3
CAS No.	56187-89-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 50 mg/mL (191.34 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.8267 mL	19.1336 mL	38.2673 mL	95.6681 mL
	5 mM	0.7653 mL	3.8267 mL	7.6535 mL	19.1336 mL
	10 mM	0.3827 mL	1.9134 mL	3.8267 mL	9.5668 mL
	20 mM	0.1913 mL	0.9567 mL	1.9134 mL	4.7834 mL
	50 mM	0.0765 mL	0.3827 mL	0.7653 mL	1.9134 mL
	100 mM	0.0383 mL	0.1913 mL	0.3827 mL	0.9567 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Dougados M, et al. Ximoprofen in ankylosing spondylitis. A double blind placebo controlled dose ranging study. Scand J Rheumatol. 1994;23(5):243-8. 2. Taylor IW, et al. Pharmacokinetics of the anti-inflammatory drug ximoprofen in healthy young and elderly subjects: comparison with elderly rheumatic patients. Br J Clin Pharmacol. 1991 Aug;32(2):242-5. 3. Taylor IW, et al. Pharmacokinetics of the anti-inflammatory drug ximoprofen in healthy subjects and in disease states. Eur J Clin Pharmacol. 1991;40(1):101-6. 4. Morris GR, et al. Determination of ximoprofen and its metabolites in human urine by high-performance liquid chromatography with ultraviolet absorbance detection. J Chromatogr. 1990 Sep 14;530(2):377-85.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

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μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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