Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WKYMVM 2TFA(187986-17-0(free base)) 是一种 N-甲酰肽受体 (FPR1) 激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 879 | 现货 | ||
5 mg | ¥ 3,290 | 现货 | ||
10 mg | ¥ 4,770 | 现货 | ||
25 mg | ¥ 7,380 | 现货 | ||
50 mg | ¥ 9,950 | 现货 | ||
100 mg | ¥ 13,300 | 现货 |
产品描述 | WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist. |
体外活性 | Neutrophils are activated by WKYMVM through FPRL1 and that FPRL2 is a chemotactic receptor transducing signals in myeloid cells[1]. |
体内活性 | Using blood samples withdrawn from 28 AL patients and 31 healthy controls, found that, in the absence of exogenous WKYMVm, WKYMVm receptor and bactericidal activity did not differ between patients and controls.?Addition of WKYMVm markedly increased the bactericidal activities of these cells in a dose-dependent manner.?During induction chemotherapy, there were significant increases in bactericidal activity in the presence and absence of 1nM WKYMVm, with higher bactericidal activities at the time of complete remission than at the time of diagnosis or on day 15.?During consolidation chemotherapy, WKYMVm had no effect on bactericidal activities.?Patients showed significant increase in the concentrations of TNF alpha, IL-1b, IL-6 and IL-8, but significant decrease in the concentrations of IL-2, IL-4 and IL-12.?TNF alpha, IL-1b and IL-6 showed significant negative correlations with bactericidal activities of patient neutrophils at time of diagnosis, and IL-4 showed a significant positive correlation with bactericidal activities,these findings indicate that WKYMVm enhances bactericidal activity in patients with AL[2]. |
分子量 | 1084.16 |
分子式 | C45H63F6N9O11S2 |
CAS No. | T7484L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (50.73 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.9224 mL | 4.6119 mL | 9.2237 mL | 23.0593 mL |
5 mM | 0.1845 mL | 0.9224 mL | 1.8447 mL | 4.6119 mL | |
10 mM | 0.0922 mL | 0.4612 mL | 0.9224 mL | 2.3059 mL | |
20 mM | 0.0461 mL | 0.2306 mL | 0.4612 mL | 1.153 mL | |
50 mM | 0.0184 mL | 0.0922 mL | 0.1845 mL | 0.4612 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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