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Vadocaine

产品编号 T35009 CAS 72005-58-4

别名: Vadocaina, Vadocainum

Vadocaine (Vadocaina) 是一种新型的镇咳化合物，可用于局部麻醉，可用于研究中枢神经系统和心血管系统。

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Vadocaine, CAS 72005-58-4

规格	价格/CNY	货期
1 mg	￥ 995	现货
5 mg	￥ 2,520	现货
10 mg	￥ 3,710	现货
25 mg	￥ 5,980	现货
50 mg	￥ 8,270	现货
100 mg	￥ 10,900	现货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

Vadocaine (Vadocaina) is a novel analgesic compound for local anaesthesia and can be used to study the central nervous system and cardiovascular system.

体内活性

In guinea pigs, vadocaine reduced by about 70% the cough episodes induced by sulphur dioxide or ammonia. The effective dose was 2.5 mg/kg p.o., and codeine phosphate was less effective. In cats, vadocaine (3 mg/kg i.v.) inhibited by about 80% for 10 min the cough reflex initiated by mechanical irritation of the trachea. When vadocaine was given via the vertebral artery, it was about 10 times more active than by the intravenous route. Codeine was 3 times as active as vadocaine by both routes. This result indicates an important central component in the antitussive action of vadocaine. In another cat model, 5 mg/kg of vadocaine was somewhat weaker than 1 mg/kg of codeine in inhibiting the cough caused by electrical stimulation of the laryngeal nerve (Domenjoz's method). In dogs, both oral and intravenous doses of 6 mg/kg of vadocaine and 2 mg/kg of codeine were approximately equiactive, inhibiting by 60-80% the cough induced by electrical stimulation of the trachea. Concentrations of vadocaine in serum were around 1 microgram/ml during oral administration. By both routes, the antitussive activity (inhibition of cough by 50% or more) lasted at least 2 h. Vadocaine caused local anaesthesia in the guinea pig wheal preparation at concentrations of 0.25% and 0.5%, and on the guinea pig cornea at 0.5%. The duration of anaesthesia was longer than that of lidocaine. Vadocaine did not affect the guinea pig tracheal strip preparation.[1]

别名	Vadocaina, Vadocainum
分子量	304.43
分子式	C18H28N2O2
CAS No.	72005-58-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 60 mg/mL (197.09 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2848 mL	16.4241 mL	32.8483 mL	82.1207 mL
	5 mM	0.657 mL	3.2848 mL	6.5697 mL	16.4241 mL
	10 mM	0.3285 mL	1.6424 mL	3.2848 mL	8.2121 mL
	20 mM	0.1642 mL	0.8212 mL	1.6424 mL	4.106 mL
	50 mM	0.0657 mL	0.3285 mL	0.657 mL	1.6424 mL
	100 mM	0.0328 mL	0.1642 mL	0.3285 mL	0.8212 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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容积 (起始)

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参考文献

1. Männistö PT, et al. Antitussive action of the new anilide derivative vadocaine hydrochloride compared with codeine phosphate in four animal models. Arzneimittelforschung. 1988 Apr;38(4A):598-604. 2. Paakkari I, et al. Cardiovascular and ventilator effects of vadocaine hydrochloride in urethane-anaesthetized rats and guinea-pigs. Arzneimittelforschung. 1988 Apr;38(4A):617-9.2. 3. Karttunen P, et al. Studies on the nonspecific central nervous system effects of the novel antitussive compound vadocaine hydrochloride. Arzneimittelforschung. 1988 Apr;38(4A):605-8. 4. Silvasti M, et al. The single dose and steady-state pharmacokinetics of a vadocaine tablet in healthy human volunteers. Int J Clin Pharmacol Ther Toxicol. 1989 Nov;27(11):558-63.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

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给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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