Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mildronate dihydrate 是心血管保护药,可竞争性的抑制BBOX1和OCTN2。它能够诱导长链脂肪酸代谢从线粒体向过氧化物酶体的重定向。Mildronate 能够作用于人重组 BBOX (IC50:34-62 μM),以及人OCTN2 (EC50:21 μM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 257 | 现货 | ||
10 mg | ¥ 413 | 现货 | ||
25 mg | ¥ 662 | 现货 | ||
50 mg | ¥ 973 | 现货 | ||
1 mL * 10 mM (in H2O) | ¥ 455 | 现货 |
产品描述 | Mildronate dihydrate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption. |
靶点活性 | OCTN2 (human):21 μM (EC50), BBOX (human recombinant):34-62 μM (IC50) |
体外活性 | Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively. [1] |
体内活性 | Mildronate administered orally to rats for 10 days (150 mg/kg) elicits a reduction in myocardial free camitine and long-chain acyl carnitine content by 63.7 and 74.3%, respectively. Mildronate treatment (100 mg/kg, orally) subsequent administration of isoproterenol results in a reduction in free camitine concentration by 48.7% in comparison with the rats receiving isoproterenol. A prior administration of Mildronate effectively protects the myocardium from isoproterenol-induced variations in the content of ATP and myocardial energy charge, as well as preventing a rise in creatine phosphokinase and lactic dehydrogenase activity. [1] Mildronate (200 mg/kg) long-term treatment significantly increases the rate of insulin-stimulated glucose uptake by 35% and the expression of glucose transporter 4 (1.7-fold increase), hexokinase II (2.1-fold increase), insulin receptor proteins (2.5-fold increase) and carnitine palmitoyltransferases IA (2.2-fold increase) in mouse hearts. Mildronate long-term treatment statistically significantly decreases fed state blood glucose from 6 to 5 mM. [2] Mildronate reduces the azidothymidine-induced alterations in mouse brain tissue. Mildronate (50 mg/kg) normalizes the increase in caspase-3, cellular apoptosis susceptibility protein (CAS) and iNOS expression. Mildronate also normalizes the changes in cytochromec oxidase (COX) expression, reduces the expression of glial fibrillary acidic protein (GFAP) and cellular infiltration. [3] |
别名 | Meldonium, 米屈肼(二水合物), Mildronate |
分子量 | 182.22 |
分子式 | C6H18N2O4 |
CAS No. | 86426-17-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 5.4879 mL | 27.4394 mL | 54.8787 mL | 137.1968 mL |
5 mM | 1.0976 mL | 5.4879 mL | 10.9757 mL | 27.4394 mL | |
10 mM | 0.5488 mL | 2.7439 mL | 5.4879 mL | 13.7197 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mildronate dihydrate 86426-17-7 Others Meldonium dihydrate Quaterin dihydrate inhibit Meldonium Mildronate Dihydrate 米屈肼(二水合物) MET-88 dihydrate Inhibitor Mildronate inhibitor