store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Linsidomine hydrochloride (SIN-1 chloride) 是莫西多明的代谢产物,具有舒张血管、抑制血小板聚集和抗心绞痛的活性。在心肌缺血-再灌注模型中,Linsidomine hydrochloride 减少心肌坏死和再灌注诱导的内皮功能障碍,与海绵体的作用机制涉及一氧化氮的释放有关。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 262 | 现货 | ||
5 mg | ¥ 597 | 现货 | ||
10 mg | ¥ 998 | 现货 | ||
25 mg | ¥ 1,790 | 现货 | ||
50 mg | ¥ 2,680 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 618 | 现货 |
产品描述 | Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release. |
体外活性 | SIN-1 decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion [1][2]. |
体内活性 |
SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits a potent vasorelaxant effect and inhibition of platelet aggregation.[1] SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.[2] |
别名 | SIN-1 chloride |
分子量 | 206.63 |
分子式 | C6H11ClN4O2 |
CAS No. | 16142-27-1 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (108.9 mM), Sonication and heating to 60℃ are recommended.
H2O: 45.0 mg/mL (217.8 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 4.8396 mL | 24.1978 mL | 48.3957 mL | 120.9892 mL |
5 mM | 0.9679 mL | 4.8396 mL | 9.6791 mL | 24.1978 mL | |
10 mM | 0.484 mL | 2.4198 mL | 4.8396 mL | 12.0989 mL | |
20 mM | 0.242 mL | 1.2099 mL | 2.4198 mL | 6.0495 mL | |
50 mM | 0.0968 mL | 0.484 mL | 0.9679 mL | 2.4198 mL | |
100 mM | 0.0484 mL | 0.242 mL | 0.484 mL | 1.2099 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Linsidomine hydrochloride 16142-27-1 Others SIN 1 Chloride SIN-1 Chloride SIN-1 chloride SIN1 Chloride Linsidomine Hydrochloride Inhibitor inhibitor inhibit