keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Larazotide acetate 是合成肽,它起到紧密连接调节器的作用,并将泄漏连接反转到它们的常闭状态。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 578 | 现货 | ||
5 mg | ¥ 1,210 | 现货 | ||
10 mg | ¥ 1,820 | 现货 | ||
25 mg | ¥ 3,990 | 现货 | ||
50 mg | ¥ 5,680 | 现货 | ||
100 mg | ¥ 7,930 | 现货 |
产品描述 | Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state. |
体外活性 | Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells and it also inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines. |
体内活性 | Larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure when tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice. |
分子量 | 785.89 |
分子式 | C34H59N9O12 |
CAS No. | 881851-50-9 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 16.67 mg/mL (21.21 mM), Sonication is recommended.
DMSO: 3.2 mg/mL (4.07 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 1.2724 mL | 6.3622 mL | 12.7244 mL | 31.8111 mL |
H2O | 5 mM | 0.2545 mL | 1.2724 mL | 2.5449 mL | 6.3622 mL |
10 mM | 0.1272 mL | 0.6362 mL | 1.2724 mL | 3.1811 mL | |
20 mM | 0.0636 mL | 0.3181 mL | 0.6362 mL | 1.5906 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Larazotide acetate 881851-50-9 Cytoskeletal Signaling Gap Junction Protein inhibit Larazotide Larazotide Acetate Inhibitor inhibitor