Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KL201 是一种昼夜节律调制器,是 CRY1选择性的 稳定剂, 对 CRY2 没有稳定作用。KL201 延长了细胞和组织中的昼夜节律周期。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 849 | 现货 | ||
5 mg | ¥ 1,980 | 现货 | ||
10 mg | ¥ 3,730 | 现货 | ||
25 mg | ¥ 5,970 | 现货 | ||
50 mg | ¥ 8,380 | 现货 | ||
100 mg | ¥ 11,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,190 | 现货 |
产品描述 | KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. |
体外活性 | KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc while not affecting cellular viability[1]. KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3[1]. KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants[1]. |
分子量 | 388.28 |
分子式 | C17H14BrN3OS |
CAS No. | 302939-48-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (643.87 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5755 mL | 12.8773 mL | 25.7546 mL | 64.3865 mL |
5 mM | 0.5151 mL | 2.5755 mL | 5.1509 mL | 12.8773 mL | |
10 mM | 0.2575 mL | 1.2877 mL | 2.5755 mL | 6.4387 mL | |
20 mM | 0.1288 mL | 0.6439 mL | 1.2877 mL | 3.2193 mL | |
50 mM | 0.0515 mL | 0.2575 mL | 0.5151 mL | 1.2877 mL | |
100 mM | 0.0258 mL | 0.1288 mL | 0.2575 mL | 0.6439 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
KL201 302939-48-6 Others CRY1 Inhibitor Per2-dLuc FBXL3 inhibit clock circadian cryptochrome KL-201 KL 201 inhibitor