Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DDP-38003 trihydrochloride 是一种新型,可口服的KDM1A/LSD1抑制剂,IC50值为84 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 15,800 | 10-14周 |
DDP-38003 trihydrochloride 的其他形式现货产品:
产品描述 | DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM. |
靶点活性 | KDM1A/LSD1:84 nM |
体外活性 | DDP-38003 inhibits KDM1A with an IC 50 of 84 nM. DDP-38003 is more active in reducing the colony-forming ability and in inducing the differentiation of THP-1 cells than the 1R, 2S analogue [1]. |
体内活性 | DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 has the potential as cancer therapeutic [1]. |
分子量 | 459.84 |
分子式 | C21H29Cl3N4O |
CAS No. | T10983 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (217.47 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1747 mL | 10.8733 mL | 21.7467 mL | 54.3667 mL |
5 mM | 0.4349 mL | 2.1747 mL | 4.3493 mL | 10.8733 mL | |
10 mM | 0.2175 mL | 1.0873 mL | 2.1747 mL | 5.4367 mL | |
20 mM | 0.1087 mL | 0.5437 mL | 1.0873 mL | 2.7183 mL | |
50 mM | 0.0435 mL | 0.2175 mL | 0.4349 mL | 1.0873 mL | |
100 mM | 0.0217 mL | 0.1087 mL | 0.2175 mL | 0.5437 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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