Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-677, serving as an inactive control for BAY-678, is distinguished by BAY-678's capabilities as an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), showcasing a high potency with an IC50 of 20 nM[1]. Furthermore, BAY-678 has been publicly nominated as a chemical probe by the Structural Genomics Consortium (SGC)[2].
产品描述 | BAY-677, serving as an inactive control for BAY-678, is distinguished by BAY-678's capabilities as an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), showcasing a high potency with an IC50 of 20 nM[1]. Furthermore, BAY-678 has been publicly nominated as a chemical probe by the Structural Genomics Consortium (SGC)[2]. |
分子量 | 400.35 |
分子式 | C20H15F3N4O2 |
CAS No. | 2117404-84-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (124.89 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4978 mL | 12.4891 mL | 24.9781 mL | 62.4454 mL |
5 mM | 0.4996 mL | 2.4978 mL | 4.9956 mL | 12.4891 mL | |
10 mM | 0.2498 mL | 1.2489 mL | 2.4978 mL | 6.2445 mL | |
20 mM | 0.1249 mL | 0.6245 mL | 1.2489 mL | 3.1223 mL | |
50 mM | 0.05 mL | 0.2498 mL | 0.4996 mL | 1.2489 mL | |
100 mM | 0.025 mL | 0.1249 mL | 0.2498 mL | 0.6245 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BAY-677 2117404-84-7 Others BAY677 BAY 677 Inhibitor inhibitor inhibit