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ADU-S100 disodium salt

产品编号 T10252 CAS 1638750-95-4

别名: ML RR-S2 CDA disodium salt, MIW815 disodium salt

ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING).

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ADU-S100 disodium salt Chemical Structure

ADU-S100 disodium salt, CAS 1638750-95-4

规格	价格/CNY	货期
5 mg	待询	5日内发货
50 mg	待询	5日内发货
100 mg	待询	5日内发货

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ADU-S100 disodium salt 的其他形式现货产品:

ADU-S100 ammonium salt

其他形式的 ADU-S100 disodium salt:

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING).
体外活性	ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
体内活性	ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose-response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicits maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%.
细胞实验	Cryopreserved hPBMCs are thawed and 1×10^6 cells per well are plated in a 96 well plate in RPMI media supplemented with 10% FBS, 1% non-essential amino acids, 1% penicillin/streptomycin, L-glutamine, 10 mM HEPES buffer, 1 mM Sodium Pyruvate, 0.055 mM β-ME at 37°C with 5% CO2. Cells are stimulated with 10 μM ADU-S100 or ML cGAMP for 6 hours and supernatants are harvested. Supernatants are diluted 1:2 and assayed for IFN-α protein using Cytometric Bead Array (CBA) Human Flex Set. Data is collected using a FACSVerse cytometer.
动物实验	WT C57BL/6 mice are inoculated with 5×10^4 B16.F10 cells in the left flank (n=8). When tumor volumes are 100 mm3 mice receive three IT doses of either ML RR-S2 CDG (25 μg), ADU-S100 (50 μg), or HBSS as control. WT C57BL/6 mice are inoculated with 5×10^4 B16.F10 cells in the left flank (n=5). When tumor volumes are 100 mm3 they received three IT doses of ADU-S100 at 5, 25, 50, or 100 μg or HBSS as control. WT C57BL/6 mice are inoculated with 5×104 B16.F10 cells in the left flank (n=8). When tumor volumes are 100 mm3 they receive three IT doses of 100 μg ADU-S100 or HBSS as control. Treatments are administered on days 13, 17, and 20 and tumor measurements are taken twice weekly. Results are shown as percent survival by Log-rank (Mantel-Cox) test (A and C).

别名	ML RR-S2 CDA disodium salt, MIW815 disodium salt
分子量	736.52
分子式	C20H24N10Na2O10P2S2
CAS No.	1638750-95-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 300 mg/mL (408.44 mM), Sonication is recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
H2O	1 mM	1.3577 mL	6.7887 mL	13.5774 mL	33.9434 mL
	5 mM	0.2715 mL	1.3577 mL	2.7155 mL	6.7887 mL
	10 mM	0.1358 mL	0.6789 mL	1.3577 mL	3.3943 mL
	20 mM	0.0679 mL	0.3394 mL	0.6789 mL	1.6972 mL
	50 mM	0.0272 mL	0.1358 mL	0.2715 mL	0.6789 mL
	100 mM	0.0136 mL	0.0679 mL	0.1358 mL	0.3394 mL

计算器

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参考文献

1. Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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