Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) 是一种医药中间体。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 278 | 现货 | ||
10 mg | ¥ 393 | 现货 | ||
25 mg | ¥ 659 | 现货 | ||
50 mg | ¥ 969 | 现货 | ||
100 mg | ¥ 1,430 | 现货 | ||
200 mg | ¥ 2,130 | 现货 | ||
500 mg | ¥ 3,450 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 259 | 现货 |
产品描述 | 7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) (3,4-Dihydro-7-hydroxycarbostyril) is a kind of pharmaceutical intermediate. |
体外活性 | ?VPC-80051 as the first small molecule inhibitor of hnRNP A1 splicing activity discovered to date by using a computer-aided drug discovery approach. The inhibitor was developed to target the RNA-binding domain (RBD) of hnRNP A1. Further experimental evaluation demonstrated that VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. This study lays the groundwork for future structure-based development of more potent and selective small molecule inhibitors of hnRNP A1?RNA interactions aimed at altering the production of cancer-specific alternative splice isoforms[1]. |
别名 | 3,4-Dihydro-7-hydroxycarbostyril, 7-羟基-2-喹诺酮 |
分子量 | 161.16 |
分子式 | C9H7NO2 |
CAS No. | 70500-72-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1mg/ml, Sonication is recommended.
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
7-Hydroxycarbostyril 70500-72-0 Others 3,4-Dihydro-7-hydroxycarbostyril 7 Hydroxycarbostyril 7Hydroxycarbostyril 7-羟基-2-喹诺酮 Inhibitor inhibitor inhibit