Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 294 | 5日内发货 |
(S,R,S)-AHPC-PEG4-NH2 hydrochloride 的其他形式现货产品:
产品描述 | (S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology. |
体外活性 | (S,R,S)-AHPC-PEG4-NH2 hydrochloride, extracted from patent US20170008904A1, can be used in the synthesis of compound A1895 in example 3[1]. |
别名 | E3 ligase Ligand-Linker Conjugates 7, VH032-PEG4-NH2 hydrochloride, VHL Ligand-Linker Conjugates 4 hydrochloride |
分子量 | 700.29 |
分子式 | C32H50ClN5O8S |
CAS No. | 2064292-52-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (71.40 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 1.428 mL | 7.1399 mL | 14.2798 mL | 35.6995 mL |
5 mM | 0.2856 mL | 1.428 mL | 2.856 mL | 7.1399 mL | |
10 mM | 0.1428 mL | 0.714 mL | 1.428 mL | 3.5699 mL | |
20 mM | 0.0714 mL | 0.357 mL | 0.714 mL | 1.785 mL | |
50 mM | 0.0286 mL | 0.1428 mL | 0.2856 mL | 0.714 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(S,R,S)-AHPC-PEG4-NH2 hydrochloride 2064292-52-8 Others VH032-PEG4-NH2 Hydrochloride (S,R,S) AHPC PEG4 NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 7 VHL Ligand-Linker Conjugates 4 Hydrochloride VH032-PEG4-NH2 hydrochloride VHL Ligand-Linker Conjugates 4 hydrochloride (S,R,S)AHPCPEG4NH2 hydrochloride (S,R,S)-AHPC-PEG-4-NH2 hydrochloride AHPC-PEG4-NH2 Hydrochloride Inhibitor inhibitor inhibit