COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.

Cat. No.	Product Name	CAS No.	Purity
TN4446	Longiferone B 化合物 TN4446	1639810-67-5	98%
TN4446	Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression.
T10152L	4-Methylamino antipyrine hydrochloride 化合物 T10152L	856307-27-2	98%
T10152L	4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibit...
TN4420	Latifolin 化合物 TN4420	10154-42-4	98%
TN4420	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
TN3922	Effusanin E 化合物 TN3922	76470-15-0	98%
TN3922	Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
TN4586	Mulberrofuran A 化合物 TN4586	68978-04-1	98%
TN4586	Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydroxy...
TN4584	Morolic acid 化合物 TN4584	559-68-2	98%
TN4584	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent change...
TN5019	Siegeskaurolic acid 化合物Siegeskaurolic acid	52645-97-3	98%
TN5019	Siegeskaurolic acid 是一种具有抗炎活性的天然产物。
T13263	COX/5-LO-IN-1 化合物 T13263	154355-75-6	98%
T13263	COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.
TN4879	Questinol 化合物 TN4879	35688-09-6	98%
TN4879	Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit th...
TN3070	4beta-Hydroxywithanolide E 化合物 TN3070	54334-04-2	98%
TN3070	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
T15630	Tilmacoxib 替马考昔	180200-68-4	98%
T15630	Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).
T15449	GW-406381 化合物 T15449	221148-46-5	98%
T15449	GW406381 is a highly selective inhibitor of cyclooxygenase-2 (COX-2). GW406381 also attenuates spontaneous ectopic discharge in the sural nerves of rats followin...
TN4162	Goshonoside F5 化合物 TN4162	90851-28-8	98%
TN4162	Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN3810	Dehydroperilloxin 化合物 TN3810	263241-09-4	98%
TN3810	Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC(50) value of 30.4 microM.
T12419	PF-04634817 succinate 化合物 T12419	2140301-98-8	98%
T12419	PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.
TN4581	Moracin D 化合物 TN4581	69120-07-6	98%
TN4581	Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization o...
TN1562	Dehydromiltirone 去氢丹参新酮	116064-77-8	98%
TN1562	Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
TMA0291	Dehydroglyasperin D 化合物 TMA0291	517885-72-2	98%
TMA0291	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
T11605	(-)-Ibuprofenamide 化合物 T11605	121839-78-9	98%
T11605	(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.
T13160	Timegadine 替美加定	71079-19-1	98%
T13160	Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM f...