Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
TP1007 | β-Amyloid (1-42), human
大豆肽
|
107761-42-2 | 99.52% |
|
β-Amyloid (1-42), human 是一种由 42 个氨基酸组成的肽,在阿尔茨海默病的发病机制中起关键作用。 | ||||
TN1798 | Isorosmanol
异迷迭香酚
|
93780-80-4 | 98.85% |
|
Isorosmanol 具有抗氧化、神经保护和神经营养作用,可能用于老年性疾病,如认知功能下降和色素沉着。 | ||||
T19011 | Hoechst 34580
化合物Hoechst 34580
|
23555-00-2 | 98.84% |
|
Hoechst 34580 (HOE 34580) 是细胞渗透性荧光染料,可用于 DNA 和核染色。 | ||||
T14525 | Begacestat
化合物 T14525
|
769169-27-9 | 98% |
|
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas... | ||||
TN3410 | Anatabine
化合物 TN3410
|
581-49-7 | 98% |
|
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime... | ||||
TN1653 | Fustin
黄颜木素
|
20725-03-5 | 98% |
|
Fustin 是植物漆树 (Rhus verniciflua Stokes) 的植物性黄烷醇成分。 Fustin 对 6-羟基多巴胺诱导的神经元细胞死亡具有保护作用。 | ||||
TN1919 | (+)-Medioresinol
梣皮树脂醇
|
40957-99-1 | 98% |
|
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th... | ||||
TN4865 | Putraflavone
化合物 TN4865
|
23624-21-7 | 98% |
|
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging. | ||||
TN3618 | Cedrin
化合物 TN3618
|
75513-81-4 | 98% |
|
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s... | ||||
TN4571 | Mirabijalone D
化合物 TN4571
|
485811-84-5 | 98% |
|
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells. | ||||
T19013 | Hoechst 34580 tetrahydrochloride
化合物 T19013
|
T19013 | 98% |
|
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei. | ||||
T10453 | BACE1-IN-5
化合物 T10453
|
2581114-83-0 | 98% |
|
BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂,IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ,IC50为 0.82 nM。并且,BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。 | ||||
T19142 | 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
化合物 T19142
|
566169-98-0 | 98% |
|
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM). | ||||
TN3218 | 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
化合物 TN3218
|
100667-52-5 | 98% |
|
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may... | ||||
TN4635 | Neoechinulin A
化合物 TN4635
|
51551-29-2 | 98% |
|
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ... | ||||
T7003 | Leucomethylene blue mesylate
化合物TRx0237 mesylate
|
1236208-20-0 | 99.99% |
|
Leucomethylene blue mesylate (TRx0237 mesylate) 是一种 Methylene blue (亚甲基蓝)的还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。它是一种具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki=为0.12 μM),可用于阿尔兹海默症的研究。 | ||||
T4398 | LX2343
化合物LX2343
|
333745-53-2 | 99.92% |
|
LX2343 是一种非 ATP 竞争性 PI3K 抑制剂,IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂,IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。 | ||||
T4S0350 | Licochalcone B
甘草查尔酮 B
|
58749-23-8 | 99.9% |
|
Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ,分解预先形成的 Aβ42原纤维,并通过螯合金属离子抑制金属诱导的 Aβ42聚集。 | ||||
T6708 | Tolcapone
托卡朋
|
134308-13-7 | 99.89% |
|
Tolcapone (Ro 40-7592) 是一种选择性,具有口服活性的外周和中枢COMT 抑制剂,在肝脏中对 COMT 的IC50为 773 nM。它还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂,可诱导氧化应激导致神经母细胞瘤细胞凋亡和抑制肿瘤生长。 | ||||
TP1229 | β-Amyloid (1-15)
β-淀粉样蛋白 (1-15)
|
183745-81-5 | 99.88% |
|
β-Amyloid (1-15) (Amyloid β-Protein (1-15)) 是 β-淀粉样蛋白片段,可用于研究阿尔茨海默病。 |