NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product Name	CAS No.	Purity
TN3070	4beta-Hydroxywithanolide E 化合物 TN3070	54334-04-2	98%
TN3070	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
T12942	SN50 化合物 T12942	213546-53-3	98%
T12942	SN50 is a cell permeable NF-κB translocation inhibitor.
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid 化合物 TN3931	57719-81-0	98%
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
T11018	DHMEQ racemate 化合物 T11018	287194-38-1	98%
T11018	DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
TN4162	Goshonoside F5 化合物 TN4162	90851-28-8	98%
TN4162	Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4315	Isonardosinone 化合物 TN4315	27062-01-7	98%
TN4315	Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-ÎºB- and MAPK-mediated inflammatory pathways.
TN1504	Citreorosein 化合物Citreorosein	481-73-2	98%
TN1504	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
TN1094	Ginsenoside Rg6 人参皂苷 Rg6	147419-93-0	98%
TN1094	Ginsenoside Rg6 抑制人淋巴瘤 JK 细胞增殖并诱导其凋亡，在 HepG2 细胞中抑制 TNF-α 诱导的 NF-κB 转录活性，IC50为 29.34 μM。
TN1562	Dehydromiltirone 去氢丹参新酮	116064-77-8	98%
TN1562	Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
TN1960	Mussaenoside 化合物Mussaenoside	64421-27-8	98%
TN1960	Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TN4399	Kushenol C 化合物 TN4399	99119-73-0	98%
TN4399	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
TN4648	Nepetoidin B 化合物Nepetoidin B	55486-06-1	98%
TN4648	Nepetoidin B 具有抗真菌、抗细菌和抗炎作用，它可以抑制 LPS 刺激的 NO 生成，可能是通过调节 RAW 264.7 细胞中由 MKP-5/NF-ÎºB 通路介导的 iNOS 。
TN4046	Excisanin A 化合物 TN4046	78536-37-5	98%
TN4046	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T12975	Sootepin D 化合物 T12975	1154518-97-4	98%
T12975	Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.
TN1359	Aflatoxin G1 黄曲霉毒素G1	1165-39-5	98%
TN1359	Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
TN3517	Bisacurone 化合物 TN3517	120681-81-4	98%
TN3517	Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN2641	15-Methoxypinusolidic acid 化合物 TN2641	769928-72-5	98%
TN2641	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN5153	Torilin 窃衣素	13018-10-5	98%
TN5153	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF...
TN5138	Teuclatriol 化合物 TN5138	152110-17-3	98%
TN5138	Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of 312...
TN3614	Cearoin 化合物 TN3614	52811-37-7	98%
TN3614	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...