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Search Results for " wnt3a "

Targets Recommended: Wnt/beta-catenin

3

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1263	Fz7-21 (Ac)-LPSDDLEFWCHVMY-NH2	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) 是一种 Frizzled 7 (FZD 7) 受体的肽抑制剂，能够选择性的与FZD7 CRD 亚类结合。它还阻断了WNT3A 介导的β-catenin 在小鼠L 细胞中的稳定作用。它对外源性WNT3A 刺激和转染WNT3A 或WNT1的HEK293细胞Wnt/β-catenin 信号传导有损伤。
T77780	Zamaporvint RXC004	Others	Others
	Zamaporvint (RXC004) 是一种具有选择性、口服活性和有效性的 Wnt 途径抑制剂，作用于膜结合脂肪酰转移酶 Porcupine，阻断 Wnt 配体棕榈酰化、分泌及通路活化。Zamaporvint 在多种癌细胞系中显示出抗肿瘤和抗增殖活性。
T36684	Ipivivint
	Ipivivint, a first-in-class, orally active and potent CDC-like kinase (CLK) inhibitor, inhibits CLK1 (IC50=1.4 μM), CLK2 (IC50=0.002 μM) and CLK3 (IC50=0.022 μM). Ipivivint reduces Wnt pathway signaling gene expression through inhibiting CLK activity and serine and arginine rich splicing factor (SRSF) phosphorylation and disrupting spliceosome activity. Ipivivint can be used for the research of cancer[1]. Ipivivint (SW480 cells; 0.01~10 μM; 1 hour) potently inhibits SRSF5/6 phosphorylation[1].Ip...

化合物

Cat.No: TP1263

Synonym: (Ac)-LPSDDLEFWCHVMY-NH2

Target: Wnt/beta-catenin

Cat.No: T77780

Synonym: RXC004

Target: Others

Cat.No: T36684

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06987	Wnt Surrogate/Wnt3a Protein, Recombinant Wnt 3a,wnt3a,Wnt	Human	HEK293 Cells
	Wnt Surrogate/Wnt3a Protein, Recombinant is expressed in HEK293 mammalian cells with hFc tag.
TMPH-01961	Wnt3a Protein, Human, Recombinant (His)	Human	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro). Wnt3a Protein, Human, Recombinant (His) is expressed in E. coli ...
TMPH-02859	Wnt3a Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro). Wnt3a Protein, Mouse, Recombinant (His) is expressed in E. coli ...
TMPY-02115	R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His) CRISTIN1,THSD2,R-spondin 3,PWTSR	Human	HEK293 Cells
	R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s...
TMPH-02436	5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) TPBG,Trophoblast glycoprotein,Wnt-activated inhibit...	Cynomolgus	E. coli
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.9 kDa and the accession number is Q4R8Y9.
TMPH-02437	5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) TPBG,WAIF1,Wnt-activated inhibitory factor 1,Tropho...	Cynomolgus	HEK293 Cells
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 39.9 kDa and the accession number is Q4R8Y9.
TMPH-03392	5T4/TPBG Protein, Rat, Recombinant (His & SUMO) Wnt-activated inhibitory factor 1,Trophoblast glyco...	Rat	E. coli
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 51.8 kDa and the accession number is Q5PQV5.

重组蛋白

Wnt Surrogate/Wnt3a Protein, Recombinant

Cat.No: TMPY-06987

Species: Human

Expression System: HEK293 Cells

Wnt3a Protein, Human, Recombinant (His)

Cat.No: TMPH-01961

Species: Human

Expression System: E. coli

Wnt3a Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02859

Species: Mouse

Expression System: E. coli

R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)

Cat.No: TMPY-02115

Species: Human

Expression System: HEK293 Cells

5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-02436

Species: Cynomolgus

Expression System: E. coli

5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc)

Cat.No: TMPH-02437

Species: Cynomolgus

Expression System: HEK293 Cells

5T4/TPBG Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03392

Species: Rat

Expression System: E. coli

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