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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T27837	Linzagolix	GNRH Receptor	GPCR/G Protein
	Linzagolix 是一种口服有活性的非多肽GnRH 拮抗剂。可用于研究子宫肌瘤、子宫腺肌症、子宫内膜异位症。
T35054	Vilaprisan BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670	Progesterone Receptor	Others
	Vilaprisan (BAY 1002670) 是一种新型可口服且具有选择性的黄体酮受体调节剂 (SPRM)，对子宫肌瘤 (UF) 具有抗增殖活性，可用于研究子宫肌瘤。
T25742	Linzagolix choline	GNRH Receptor	GPCR/G Protein
	Linzagolix choline 是一种可口服的非肽类的促性腺激素释放激素（GnRH）拮抗剂。可用于研究子宫肌瘤和子宫内膜异位症相关疼痛。
T13572	Cancer-Targeting Compound 1	Others	Others
	Cancer-Targeting Compound 1可用于激素相关癌症的研究，包括治疗或预防肌瘤、子宫平滑肌瘤、多囊卵巢综合征或激素依赖性癌等等。
T32684	Leuprolide (1-3) Leuprorelin
	Leuprolide (1-3) is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.
T36859	C16 Globotriaosylceramide (d18:1/16:0) C16 Globotriaosylceramide (d18:1/16:0)
	C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien...
T21308	Histrelin Supprelin LA,组氨瑞林,Histrelin Acetate	Others	Others
	Histrelin (Supprelin LA) 是促性腺激素释放激素 (GnRH) 的九肽类似物，具有增加的效力。它被认为是 GnRH 激动剂。 Histrelin 用于治疗对激素敏感的男性前列腺癌和女性子宫肌瘤。
T71149	Triptorelin pamoate
	Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, es...
T72990	BAY 1214784
	BAY 1214784是一种针对人促性腺激素释放激素受体(hGnRH-R)的高效、选择性口服活性拮抗剂，属于螺二氢吲哚衍生物化合物。该化合物能显著降低血浆促黄体激素水平，最高可达49%，同时显示出较低的药代动力学变异性和良好的耐受性，表现出研究子宫肌瘤的潜力。
T68525	Nafarelin acetate hydrate
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...

化合物

Linzagolix

Cat.No: T27837

Synonym:

Target: GNRH Receptor

Vilaprisan

Cat.No: T35054

Synonym: BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670

Target: Progesterone Receptor

Linzagolix choline

Cat.No: T25742

Synonym:

Target: GNRH Receptor

Cancer-Targeting Compound 1

Synonym: Leuprorelin

Target:

C16 Globotriaosylceramide (d18:1/16:0)

Cat.No: T36859

Synonym: C16 Globotriaosylceramide (d18:1/16:0)

Target:

Histrelin

Cat.No: T21308

Synonym: Supprelin LA,组氨瑞林,Histrelin Acetate

Nafarelin acetate hydrate

Cat.No: T68525

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T1048	Estradiol 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estradiol (E2) 是一种天然的类固醇性激素，对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。

天然产物

Estradiol

Cat.No: T1048

Synonym: 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

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