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Cat. No. | Product Name | Target | Signaling Pathways |
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T29137 |
VU0453595
VU 0453595,VU-0453595 |
AChR | Neuroscience |
VU0453595 是有效的、高选择性的、全身活性的M1正变构调节剂 (PAM, EC50=2140 nM),在精神分裂症方面有研究价值。 | |||
T68060 |
Elgodipine
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Elgodipine 显著降低了运动诱导的心绞痛系统的发生率和严重程度,能够通过独立于转录因子c-fos 和c-jun 表达的机制抑制血管平滑肌增殖。 Elgodipine 诱导的抑制是电压依赖性的。Elgodipine 是治疗心绞痛的潜在化合物。 | |||
T27680 |
JNJ-40068782
JNJ 40068782 |
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JNJ-40068782 is a potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor. | |||
T27909 |
LY 274614
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LY 274614 is a structurally novel systemically active competitive NMDA receptor antagonist. | |||
T71931 |
Clencyclohexerol
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Clencyclohexerol is an analog of clenbuterol. β-Adrenoceptor agonists, including clenbuterol, modulate protein synthesis and degradation and have therapeutic potential in muscle wasting disorders. β-adrenoceptor agonists have deleterious cardiovascular side effects when used systemically and at high concentrations. | |||
T70619 |
LY2934747
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LY2934747 is a novel, potent, and systemically bioavailable mGlu2/3 receptor agonist, exhibiting both antipsychotic and analgesic properties in vivo. | |||
T41184 |
Clocinnamox mesylate
C-CAM,NIH 10443 |
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Clocinnamox mesylate is a systemically active, irreversibleμ-opioid receptor antagonist (apparent Kivalues are 0.7, 1.9 and 5.7 nM for mouseμ,δandκreceptors respectively). | |||
T27897 |
LY 215490
LY215490,LY-215490 |
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LY 215490 is a selective, competitive and systemically active antagonist of AMPA receptor. LY 215490 has neuroprotective effect against focal ischaemia in a model of permanent MCA occlusion in the rat. | |||
T68321 |
AS1940477
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AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c... | |||
T36204 |
Methylatropine (nitrate)
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Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 μg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3 1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotin... | |||
T38844 |
MK-8245 Trifluoroacetate
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MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T0281 |
Meclocycline sulfosalicylate salt
磺基水杨酸甲氯环素,Meclutin,Mecloderm,甲环素磺基水杨酸盐,Meclan Cream |
Antibacterial; Antibiotic | Microbiology/Virology |
Meclocycline sulfosalicylate salt (Mecloderm) 是一种具有广谱抗菌活性的四环素抗生素,可预防皮肤细菌感染。 |