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Cat. No. Product Name Target Signaling Pathways
T1768 7ACC2

Mitochondrial Metabolism; Monocarboxylate transporter Membrane transporter/Ion channel; Metabolism
7ACC2 是单羧酸盐转运蛋白抑制剂,IC50为 11 nM。它还是线粒体丙酮酸转运的有效抑制剂,可抑制乳酸涌入,通过抑制乳酸通量来发挥抗癌作用。
T68317 VJ115

VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cy...

化合物

7ACC2
Cat.No: T1768
Synonym:
Target: Mitochondrial Metabolism, Monocarboxylate transporter
VJ115
Cat.No: T68317
Synonym:
Target:
TargetMol Loading
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