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15

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12516	Polyinosinic-polycytidylic acid sodium 双链聚肌胞,Poly(I:C) sodium	Apoptosis; Others; TLR	Apoptosis; Immunology/Inflammation; Others
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) 是双链 RNA 的合成类似物，是TLR3和视黄酸诱导型基因 I 受体激动剂。它可以用作疫苗佐剂，直接触发癌细胞发生凋亡，还增强先天性和适应性免疫反应，并改变肿瘤的微环境。
T5007	Benproperine phosphate 磷酸苯丙哌林,Blascorid,Pirexyl phosphate	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	Benproperine phosphate (Pirexyl phosphate) 是一种具有口服活性的，肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。它通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。它可抑制癌细胞迁移和肿瘤转移，有用于治疗止咳的潜力。
T21368	Thioproperazine Megeptil,Sulfenazin,Cephalmin,Majeptyl,Vontil,Mazeptyl
	Thioproperazine is a drug with the activity of antipsychotic.
T40480	Clenproperol
	Clenproperol is a β2-adrenergic agonist.
T81389	Properdistatin
	Properdistatin是一种衍生自thrombospondin-1 (TSP-1)结构域的小分子肽，其作用机制主要在于抑制血管生成并促进血管功能的改善，因此在黑色素瘤的研究中显示出应用潜力。
T5007L	Benproperine BRN-1258822,BRN 1258822,Pirexyl,Benproperinum,Bemproperina
	Benproperine is a bioactive molecule with antineoplastic properties.
T1369	1-Methylindazole-3-carboxylic acid	Others	Others
	1-Methylindazole-3-carboxylic acid 是一种具有适当沸点的优良溶剂。
TP1651L	Proinsulin C-peptide human acetate 醋酸胰岛素原C-肽(55-89),人,Proinsulin C-peptide human acetate (33017-11-7 Free base)	Others	Others
	Proinsulin C-peptide human acetate (Proinsulin C-peptide human acetate (33017-11-7 Free base)) 是一种由31个氨基酸残基组成的多肽，它连接胰岛素原的 A 链和 B 链以确保正确折叠，具有生物活性并调节细胞功能。
T26299	Tubulozole R46846,R 46846,R-46846
	Tubulozole is a microtubule inhibitor. It inhibits microtubule dynamics required for proper mitotic function, effectively blocking cell cycle progression and resulting in apoptosis.
TP1651	Proinsulin C-peptide (human) Proinsulin C-peptide human
	Proinsulin C-peptide (human) is a 31-amino acid peptide that connects the Proinsulin a and B chains, ensuring its proper folding, biological activity, and regulation of cellular functions.
T36863	Geranylgeranyl Pyrophosphate (ammonium salt) Geranylgeranyl Pyrophosphate (ammonium salt),GGPP
	Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco...
T63995	BuChE-IN-2
	BuChE-IN-2 是一种优良的丁基胆碱酯酶(BuChE) 抑制剂，能够作用于 BuChE (IC50: 1.28 μM) 和 NO (IC50: 0.67 μM)。BuChE-IN-2 能够抑制 Aβ 的聚集、ROS 的形成和螯合 Cu2+，表现出适当的血脑屏障 (BBB) 穿透性，能够用于阿尔茨海默病的研究。
T28157	Nephrin
	Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. Nephrin belongs to a family of highl
T68743	AZD4877 HCl
	AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur...
T38142	Phosphatidylethanolamines (soy)
	Phosphatidylethanolamine is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial m...

化合物

Polyinosinic-polycytidylic acid sodium

Cat.No: T12516

Synonym: 双链聚肌胞,Poly(I:C) sodium

Target: Apoptosis, Others, TLR

Benproperine phosphate

Cat.No: T5007

Synonym: 磷酸苯丙哌林,Blascorid,Pirexyl phosphate

Target: Others, Microtubule Associated

Thioproperazine

Cat.No: T21368

Synonym: Megeptil,Sulfenazin,Cephalmin,Majeptyl,Vontil,Mazeptyl

Cat.No: T40480

Properdistatin

Cat.No: T81389

Cat.No: T5007L

Synonym: BRN-1258822,BRN 1258822,Pirexyl,Benproperinum,Bemproperina

1-Methylindazole-3-carboxylic acid

Cat.No: T1369

Target: Others

Proinsulin C-peptide human acetate

Cat.No: TP1651L

Synonym: 醋酸胰岛素原C-肽(55-89),人,Proinsulin C-peptide human acetate (33017-11-7 Free base)

Target: Others

Cat.No: T26299

Synonym: R46846,R 46846,R-46846

Proinsulin C-peptide (human)

Cat.No: TP1651

Synonym: Proinsulin C-peptide human

Geranylgeranyl Pyrophosphate (ammonium salt)

Cat.No: T36863

Synonym: Geranylgeranyl Pyrophosphate (ammonium salt),GGPP

Cat.No: T63995

Cat.No: T28157

Cat.No: T68743

Phosphatidylethanolamines (soy)

Cat.No: T38142

Cat. No.	Product Name	Target	Signaling Pathways
T2O2683	L-Proline L-(-)-Proline,proline,脯氨酸,L-脯氨酸	Endogenous Metabolite	Metabolism
	L-Proline (proline) 是人体非必需氨基酸。它是胶原蛋白的重要组成部分，对关节和肌腱的正常运作很重要。它还有助于维持和加强心脏肌肉。

天然产物

Cat.No: T2O2683

Synonym: L-(-)-Proline,proline,脯氨酸,L-脯氨酸

Target: Endogenous Metabolite

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