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Cat. No.	Product Name	Target	Signaling Pathways
T3461	Losartan Carboxylic Acid EXP-3174,E-3174	RAAS	Endocrinology/Hormones
	Losartan Carboxylic Acid (E-3174) 是 Losartan 的活性羧酸代谢产物，是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素 II 诱导的血管平滑肌细胞反应，可以提高血浆肾素活性，降低平均动脉压。
TP2281	p53 tumor suppressor fragment	Others	Others
	p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where i
T32520	Lac repressor fragment 33-38
	Lac repressor fragment 33-38 Lys-Arg-Glu-Lys-Val fragment from lac repressor.
T12160	N6-Cyclohexyladenosine CHA,A1受体促进剂	Adenosine Receptor	GPCR/G Protein; Neuroscience
	N6-Cyclohexyladenosine (CHA) 是一种选择性腺苷 A1 受体激动剂，EC50 为 8.2 nM。
T70637	FRAN-12
	FRAN-12 is a histamine and 5-hydroxytryptamine antagonist with pressor properties.
T68183	PPMC
	The alpha-adrenoceptors blocking effect of (N-piperidinomethyl)-2-chromanne was studied in vivo and in vitro in the rat. In the pithed rat, (N-piperidinomethyl)-2-chromanne (1 mg/kg i.v.) antagonized the pressor effects induced by alpha agonists. (N-piperidinomethyl)-2-chromanne competitively antagonized the pressor effects of M7 (alpha 2-agonist) and cirazoline (alpha 1-agonist). (N-piperidinomethyl)-2-chromanne antagonized the inhibitory effects of clonidine on presynaptic alpha 2-receptors in...
T36479	Big Endothelin-1 (1-38), human
	Human Big ET-1 comprises residues 53-90 of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (hET-1), the peptide show less vasoconstrictor activity in vitro, but similar pressor effects in vivo. Former CAS-number 121014-53-7.
T76011	Adrenomedullin (16-31), human TFA
	Adrenomedullin(16-31), human TFA 为人类肾上腺髓质素(hADM)之16至31氨基酸片段，对CGRP1受体显示高亲和力。该化合物在大鼠体内可提高全身血压，但对猫无效。
T36480	Big Endothelin-1 (1-39), porcine
	The big endothelins comprise residues 53-90 (human big ET-1) and 53-91 (porcine big ET-1) of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (ET-1), both peptides show less vasoconstrictor activity in vitro, but similar pressor effects in vivo. Former CAS-number 121014-54-8.
T73216	Gepefrine
	Gepefrine为具口服活性的升压剂及拟交感神经作用剂，能有效改善动脉压早期直立性失调。
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
T68616	Pentoprilat
	Pentoprilat is a member of a series of l-glutarylindoline-2(S)-carboxylic acid derivatives. Pentopril was evaluated as an inhibitor of a cell-free preparation of angiotensin-converting enzyme (ACE) isolated from rabbit lung. Intravenous administration of incremental doses of pentopril to anesthetized normotensive rats produced a dose-related inhibition of angiotensin I (AI) pressor responses. The onset of inhibition of the A1 pressor response was rapid, and substantial inhibition occurred at 5 m...
T71205	Fosinopril-d7 sodium salt
	Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti...
T36729	Urotensin II (goby) (trifluoroacetate salt)
	Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki= 2.06 nM for the human recombinant receptor expressed in HEK293 cells).1It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM.2Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across ...

化合物

Losartan Carboxylic Acid

Cat.No: T3461

Synonym: EXP-3174,E-3174

Target: RAAS

p53 tumor suppressor fragment

Cat.No: TP2281

Target: Others

Lac repressor fragment 33-38

Cat.No: T32520

N6-Cyclohexyladenosine

Cat.No: T12160

Synonym: CHA,A1受体促进剂

Target: Adenosine Receptor

Cat.No: T70637

Cat.No: T68183

Big Endothelin-1 (1-38), human

Cat.No: T36479

Adrenomedullin (16-31), human TFA

Cat.No: T76011

Big Endothelin-1 (1-39), porcine

Cat.No: T36480

Cat.No: T73216

Cat.No: T71065

Cat.No: T68616

Fosinopril-d7 sodium salt

Cat.No: T71205

Urotensin II (goby) (trifluoroacetate salt)

Cat.No: T36729

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