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Cat. No. | Product Name | Target | Signaling Pathways |
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T1874 |
PPQ-102
PPQ102,CFTR Inhibitor,PPQ 102 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
PPQ-102 (CFTR Inhibitor) 是一种CFTR 抑制剂,可以完全抑制CFTR 氯化物电流,IC50为90 nM。 | |||
T60170 |
BLU2864
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Others | Others |
BLU2864 是一种具有口服活性的、高选择性的、ATP 竞争性的 PRKACA 抑制剂 ,IC50值为0.3 nM。BLU2864 具有抗肿瘤活性,具有用于癌症和多囊肾的研究潜力。 | |||
T39105 |
Ibiglustat succinate
GZ402671succinate,Venglustat succinate,Ibiglustat succinate,SAR402671succinate |
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Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS). It is utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease. | |||
T64174 |
Vasopressin V2 receptor antagonist 1
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Vasopressin V2 receptor antagonist 1 (Compound 4g) 是一种 vasopressin V2receptor (V2R) 拮抗剂 (Ki: 3.8 nM)。Vasopressin V2 receptor antagonist 1 可以用于研究常染色体显性多囊肾病 (ADPKD)。 | |||
T39712 |
RGLS4326
RG4326,RGLS4326 |
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RGLS4326 (RG4326) is a short oligonucleotide inhibitor of microRNA-17 (miR-17), with a pioneering role in its class. This compound, with a research focus on autosomal dominant polycystic kidney disease (ADPKD), effectively suppresses the activity of miR-17 in HeLa cells, displaying an EC50 value of 28.3 nM. | |||
T61362 |
CDK5-IN-3
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CDK5-IN-3 (compound 11) is a highly potent and selective inhibitor of CDK5, demonstrating significant inhibition with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. This compound holds promise for further investigation in the context of autosomal dominant polycystic kidney disease (ADPKD) research [1]. | |||
T73163 | CDK7-IN-20 | ||
CDK7-IN-20 是一种有效的、选择性的、不可逆的 CDK7(CDK) 抑制剂,IC50值为 4 nM。CDK7-IN-20 对 CDK7的选择性超过 CDK1、CDK2、CDK3、CDK5、CDK6、CDK9 和 CDK12的 206 倍以上。CDK7-IN-20 具有用于常染色体显性多囊肾病 (ADPKD) 研究的潜力。 | |||
T60953 | BSc5367 | ||
BSc5367 是Nek1激酶结构域的有效抑制剂,IC50值为 11.5 nM。Nek1 是一种NIMA 相关的蛋白激酶,在细胞周期调节、DNA 修复和微管调节中起着关键作用。Nek1 功能障碍在肌萎缩侧索硬化症 (ALS)、多囊肾病 (PKD) 和几种类型的放疗耐药性癌症中发挥关键作用。BSc5367 为更好的理解上述疾病提供了有用工具。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2S1837 |
Steviol
甜菊醇,NSC 226902,Hydroxydehydrostevic acid |
Others | Others |
Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达,并促进 AQP2 的降解,从而减缓肾囊肿的生长。 |