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Cat. No. Product Name Target Signaling Pathways
T8674 SR33805

Calcium Channel Membrane transporter/Ion channel; Metabolism
SR33805 是钙通道拮抗剂,在去极化和极化条件下的 EC50值分别为 4.1 和 33 nM。它阻止 L 型 Ca2+通道,可用于研究急性或慢性心脏衰竭。
T37020 Endosidin-2

ES2,Endosidin 2

Endosidin-2是一种囊外囊抑制剂,具有细胞渗透性的亚苄基苯甲酰肼,可与外囊复合体70 kDa(EXO70)亚基的外囊成分结合(Kd = 253 μM,EXO70A1)。Endosidin-2会破坏蛋白质在内质体和质膜之间的转运,从而促进蛋白质转运至液泡降解。它还能抑制 HeLa 细胞中内吞转铁蛋白向质膜的再循环,并能靶向哺乳动物 EXO70的多种异构体,导致外泌失调。Endosidin2 可作为工具分子研究胞吐。
T27089 CRT0066854

CRT0066854 HCl,CRT-0066854 HCl,CRT 0066854,CRT-0066854

CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854 was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids.
T37907 DL 175

Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.
T36998 7β,27-dihydroxy Cholesterol

7β,27-DHC,7β,27-dihydroxy Cholesterol

7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 &#181M. It increases IL-17A production in Th17-polarized isolated hum...

化合物

SR33805
Cat.No: T8674
Synonym:
Target: Calcium Channel
Endosidin-2
Cat.No: T37020
Synonym: ES2,Endosidin 2
Target:
CRT0066854
Cat.No: T27089
Synonym: CRT0066854 HCl,CRT-0066854 HCl,CRT 0066854,CRT-0066854
Target:
DL 175
Cat.No: T37907
Synonym:
Target:
7β,27-dihydroxy Cholesterol
Cat.No: T36998
Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol
Target:
TargetMol Loading
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