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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1264	Prolylleucine ((Benzyloxy)carbonyl)-L-prolyl-D-leucine	Others	Others
	Prolylleucine (((Benzyloxy)carbonyl)-L-prolyl-D-leucine) 是一种二肽，含有支链氨基酸，可以影响动物的昼夜节律和行为。
TP1858L	Phe-Met-Arg-Phe, amide acetate Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase)	Potassium Channel	Membrane transporter/Ion channel
	Phe-Met-Arg-Phe, amide acetate(64190-70-1 freebase) 剂量依赖性 (ED50=23 nM) 激活肽能尾背神经元中的 K+ 电流。这种肽似乎在大脑的某些区域与神经肽 Y 一起定位。
T27986	MCL0129 MCL-0129,MCL 0129
	MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia.
T37201	CAY10787
	CAY10787 is an oxysterol and a negative allosteric modulator of GABAAreceptors.1,2It reduces GABA-induced currents in HEK cells expressing α1β1γ2or α4β3γ2subunit-containing GABAAreceptors (IC50s = 1.5 and 1 μM, respectively).2CAY10787 (500 nM) reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons.In vivo, CAY10787 (2, 10, and 50 mg/kg) increases latency to nocifensive behaviors in t...
TP1858	Phe-Met-Arg-Phe, amide
	Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain.
T70365	JTP-4819
	JTP-4819 is a potent and selective prolyl endopeptidase (PEP) inhibitor with potential for treating Alzheimer's disease. At nanomolar concentration, JTP-4819 inhibited the degradation of substance P, arginine-vasopressin, and thyrotropin-releasing hormone by PEP in supernatants of the rat cerebral cortex and hippocampus. Repeated administration of JTP-4819 reversed the aging-induced decrease in brain substance P-like and thyrotropin-releasing hormone-like immunoreactivity, suggesting that this d...

化合物

Prolylleucine

Cat.No: TP1264

Synonym: ((Benzyloxy)carbonyl)-L-prolyl-D-leucine

Target: Others

Phe-Met-Arg-Phe, amide acetate

Cat.No: TP1858L

Synonym: Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase)

Target: Potassium Channel

MCL0129

Cat.No: T27986

Synonym: MCL-0129,MCL 0129

Phe-Met-Arg-Phe, amide

Cat. No.	Product Name	Target	Signaling Pathways
T13953	Umbellulone	Others	Others
	Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.