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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4657	WHI-P97 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	WHI-P97 是一种选择性 JAK-3抑制剂，可用于预防过敏性哮喘的研究。
T33647L	Nesosteine Lithium Nesosteine Lithium(84233-61-4 Free baes)
	Nesosteine Lithium 是一种新型的粘液调节剂，对豚鼠 Herxheimer 微休克具有抑制作用且抑制卵清蛋白诱导的组胺在致敏动物气管中的释放。Nesosteine Lithium 能够保护致敏动物免受卵清蛋白诱导的支气管痉挛但对组胺和乙酰胆碱诱导的支气管痉挛无效。
T37722	Diprovocim-1
	Diprovocim-1 is an agonist of the toll-like receptor 1/2 heterodimer.1It induces TNF-α release in THP-1 cells (EC50= 110 pM), an effect that can be inhibited by anti-TLR1 or anti-TLR2 antibodies. Diprovocim-1 (10 mg/kg) increases the production of ovalbumin-specific IgG1 in wild-type, but notTLR2-/-, mice sensitized to ovalbumin.2It also enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma mo...
T71329	Theophylline-d6
	Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F...
T38350	TAS 205
	TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sens...

化合物

WHI-P97

Cat.No: T4657

Synonym: 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉

Target: JAK

Nesosteine Lithium

Cat.No: T33647L

Synonym: Nesosteine Lithium(84233-61-4 Free baes)

Cat. No.	Product Name	Target	Signaling Pathways
T4S2164	Narirutin Naringenin-7-O-rutinoside,Isonaringin,芸香柚皮苷,柚皮芸香苷	Others; Antibacterial	Microbiology/Virology; Others
	Narirutin (Naringenin-7-O-rutinoside) 是从Citrus unshiu 中分离的活性成分之一，具有抗氧化和抗炎活性。它是一种具有抗结核效力的shikimate 激酶抑制剂。