10
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62031 | SARS-CoV-2 nsp13-IN-4 | ||
SARS-CoV-2 nsp13-IN -4 (C4 (d)) 是强效的、选择性的 nsp13 helicase 小分子抑制剂。SARS-CoV-2 nsp13-IN -4 抑制 nsp13 的 ssDNA+ ATPase 活性,IC50值为57 μM。SARS-CoV-2 nsp13-IN-4 显示广谱抗病毒作用。 | |||
T62264 |
SARS-CoV-2 nsp13-IN-2
|
||
SARS-CoV-2 nsp13-IN-2 (Compound C2) 是一种 SARS-CoV-2 非结构蛋白 13(nsp13)小分子抑制剂,能够作用于 nsp13 ssDNA+ATPase (IC50: 42 μM)。 | |||
T62375 | SARS-CoV-2 nsp13-IN-3 | ||
SARS-CoV-2 nsp13-IN-3 (Compound C3) 是一种 SARS-CoV-2 非结构蛋白 13(nsp13)小分子抑制剂,能够作用于 nsp13 ssDNA+ATPase (IC50: 32 μM)。 | |||
T79526 |
SARS-CoV-2 nsp14-IN-4
|
SARS-CoV | Microbiology/Virology |
SARS-CoV-2 nsp14-IN-4(Compound 12q)是针对SARS-CoV-2 nsp14甲基转移酶的抑制剂,具有19 nM的IC50值。此化合物没有细胞毒性,并且可穿过细胞膜。它被应用于COVID-19的相关研究。 | |||
T62413 |
SARS-CoV-2 nsp13-IN-1
|
||
SARS-CoV-2 nsp13-IN-1 (compound C1) 是一种 nsp13 (非结构蛋白 13) 的有效抑制剂。SARS-CoV-2 nsp13-IN-1 只抑制nsp13 ssDNA+ATPase (IC50: 6 μM),不抑制 ssDNA-ATPase。SARS-CoV-2 nsp13-IN-1 能够用于研究 COVID-19。 | |||
T62819 | SARS-CoV-2 nsp14-IN-2 | ||
SARS-CoV-2 nsp14-IN-2 是一种 SARS-CoV-2 Nsp14 甲基转移酶 (SARS-CoV-2 Nsp14 methyltransferase) 的有效抑制剂 (IC50: 0.093 μM)。SARS-CoV-2 nsp14-IN-2 具有抗病毒活性,并表现出血浆和肝脏 S9 稳定性。SARS-CoV-2 nsp14-IN-2 具有潜力进行 COVID-19 的研究。 | |||
T62829 | SARS-CoV-2 nsp14-IN-1 | ||
SARS-CoV-2 nsp14-IN-1 (Compound 3) 是一种典型的 SARS-CoV-2Nsp14 Mtase 双底物抑制剂 (IC50: 0.061 μM)。SARS-CoV-2 nsp14-IN-1 对人类甲基转移酶表现出良好的选择性,可拮抗 10 种人甲基转移酶(如组蛋白赖氨酸、蛋白精氨酸、DNA 和 RNA 等)。 | |||
T62248 |
SARS-CoV-2 nsp13-IN-6
|
||
SARS-CoV-2 nsp13-IN-6 (compound C5) 是一种 SARS-CoV-2 非结构蛋白 13 (nsp13) 的有效抑制剂,能够作用于 ssDNA+ATPase (IC50: 27 μM)和 ssDNA-ATPase (IC50: 33 μM)。SARS-CoV-2 nsp13-IN-6 可以用于抗 COVID-19 的研究。 | |||
T78725 | SARS-CoV-2 nsp14-IN-3 | SARS-CoV | Microbiology/Virology |
SARS-CoV-2 nsp14-IN-3 (4975)为一种针对SARS-CoV-2 Nsp14 N7-甲基转移酶的抑制剂,具有IC50值为7 μM。 | |||
T63615 |
SARS-CoV-2 nsp13-IN-5
|
||
SARS-CoV-2 nsp13-IN-5 是 SARS-CoV-2 nsp13 的有效抑制剂,能够作用于 ssDNA+ATPase (IC50: 50 μM) 和 ssDNA-ATPase (IC50: 55 μM)。SARS-CoV-2 nsp13-IN-5 能够用于抗 COVID-19 的研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01425 |
SARS-CoV-2 NSP1 Protein (His)
SARS-CoV 2 nsp1,SARS-CoV 2 Leader protein |
SARS-CoV-2 | E. coli |
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close associa... | |||
TMPK-01352 |
SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)
Plpro,PL2-PRO,pp1a,nsp1,Replicase... |
SARS | E. coli |
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Pro... | |||
TMPK-01384 |
SARS PLpro/papain-like protease Protein (His)
Papain-like Protease,PL-PRO,Replicase polyprotein 1... |
SARS | E. coli |
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro/papain-like protease Protein (... | |||
TMPY-06011 |
SARS-CoV-2 NSP10 Protein (His)
|
SARS-CoV-2 | E. coli |
NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp14 and nsp16 and possibly other subunits of the viral replication complex may be a target for the development of antiviral compounds against pathogenic coronaviruses. SARS-CoV-2 NSP10 Protein (His) is expressed in E. coli expression system. The predicted molecular weight is 15.7 ... | |||
TMPY-06012 |
SARS-CoV-2 NSP10 Protein
|
SARS-CoV-2 | E. coli |
NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp14 and nsp16 and possibly other subunits of the viral replication complex may be a target for the development of antiviral compounds against pathogenic coronaviruses. SARS-CoV-2 NSP10 Protein is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and ... | |||
TMPY-06009 |
SARS-CoV-2 NSP7 Protein
|
SARS-CoV-2 | E. coli |
NSP7 is conserved within the coronaviridae. NSP7 is a component of the coronavirus replicase polyprotein to comprise a repilication complex. NSP7 has been shown to interact with NSP10 and NSP1 which indicate that NSP7 has a founction in coronavirus-specific RNA replication mechanisms. |