Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7495 |
Hexa-D-arginine
|
Others | Others |
Hexa-D-arginine 是稳定的furin 抑制剂,能够作用于 furin (Ki:106 nM)、PACE4 (Ki:580 nM)、PC1 (Ki:13.2 nM)。它在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。 | |||
T4217 |
INF39
|
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
INF39 是无细胞毒性的NLRP3不可逆抑制剂。 | |||
T72399 | LIMK1 inhibitor BMS-4 | ||
LIMK1 inhibitorBMS-4为针对LIMK1/2的LIM Kinase (LIMK)抑制剂,能够抑制LIMK底物cofilin的磷酸化,但不具细胞毒性。 | |||
T9811 |
JAK3-IN-11
|
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JAK3- in -11 (Compound 12) 是表现出强效的、无细胞毒性、不可逆、口服活性的JAK3抑制活性,IC50值为1.7 nM,具有出色的选择性(高于其他 JAK3 亚型的588倍),共价结合到 JAK3 的 ATP-binding pocket。 JAK3-IN-11 强烈抑制 JAK3 依赖的信号转导和T 细胞增殖,是研究自身免疫性疾病的有效工具。 | |||
T71966 |
PD-128763
|
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PD-128763 is a selective inhibitor of poly(ADP-ribose) polymerase. PD-128763 has an IC50 value against the purified enzyme approximately 50X lower than 3-aminobenzamide (3-AB), a widely used specific inhibitor of the enzyme. Exposure of exponentially growing cells to a noncytotoxic concentration (0.5 mM) of PD 128763 for 2 h immediately following X irradiation increased their radiation sensitivity, modifying both the shoulder and the slope of the survival curve. When recovery from sublethal dama... |