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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T29596	Acetylaminofluorene-dG dG-8-AAF,8-AAF dG,8 AAF-dG,8-AAF-dG
	Acetylaminofluorene-dG is a carcinogenic adduct which covalently binds DNA bases and promotes mutagenesis near the adduct site.
T32418	KP-1212 KP1212,SN-1212,SN 1212,SN1212,KP 1212
	KP-1212( SN-1212) is a nucleoside designed for the treatment of HIV by viral mutagenesis.
T71126	Allixin
	Allixin is a phytoallexin found in garlic (Allium sativum) bulbs. Allixin has weak antimicrobial activity and exerts an anti-promoting activity against skin tumors induced by the chemical 12-O-tetradecanoylphorbol-13-acetate (TPA). Allixin also demonstrates an inhibitory effect on aflatoxin B1-induced mutagenesis.
T35646	4-oxo-2-Nonenal 4-oxo-2-Nonenal,4-ONE
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on prot...
T83829	2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate sodium ε-dATP
	ε-dATP是一种具有荧光性的嘌呤核苷酸2’-脱氧腺苷-5’-O-三磷酸（dATP）衍生物。它能在50至150µM的浓度范围内诱导初级小鼠脾脏T细胞和B细胞在脂多糖(LPS)或刀豆蛋白A刺激下发生姊妹染色单体交换。ε-dATP已被用于研究乙烯氯诱导的突变过程中模糊碱基配对的情况。相关的ATP衍生物ε-ATP，在300 nm激发下显示415 nm的发射峰值。
T36881	NHC-diphosphate triammonium
	NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono...
T35789	Palmitic acid-1-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 \|1. Santos, M.J., López-Jurado, M., Llopis, J., et a...
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...

化合物

Acetylaminofluorene-dG

Cat.No: T29596

Synonym: dG-8-AAF,8-AAF dG,8 AAF-dG,8-AAF-dG

Target:

KP-1212

Cat.No: T32418

Synonym: KP1212,SN-1212,SN 1212,SN1212,KP 1212

Synonym: 4-oxo-2-Nonenal,4-ONE

Target:

2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate sodium

Cat.No: T83829

Synonym: ε-dATP

Target:

NHC-diphosphate triammonium

Cat. No.	Product Name	Target	Signaling Pathways
TN2244	Sulfuretin 硫黄菊素	NF-κB; Autophagy	Autophagy; NF-κB
	Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂，IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。

天然产物

Sulfuretin

Cat.No: TN2244

Synonym: 硫黄菊素

Target: NF-κB, Autophagy

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