Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79211 |
mTOR inhibitor-11
|
mTOR | PI3K/Akt/mTOR signaling |
mTORinhibitor-11(Compound 9)是具有穿透血脑屏障能力的mTOR抑制剂,其IC50针对pS6为21 nM。该化合物还可抑制pCHK1及PDE4D,其IC50值分别为17.2 μM和17.0 μM,适用于中枢神经系统疾病的研究。 | |||
T9309 |
mTOR inhibitor 11
|
||
mTOR inhibitor 11 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T9309,CAS号为 1195785-35-3。 | |||
T79212 |
mTOR inhibitor-12
|
mTOR | PI3K/Akt/mTOR signaling |
mTORinhibitor-12(Compound 11)为选择性脑渗透性mTOR抑制剂,无遗传毒性风险,适用于中枢神经系统疾病研究。 | |||
T36084 |
PKI-179
|
||
PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo[1][2]. PKI-179 inhibits the cell proliferation, with IC50s of 22 nM and 29 nM for MDA361 and PC3 cells, respectively[1].PKI-179 shows inhibitory activity against a panel of 361 other ... | |||
T36085 | PKI-179 hydrochloride | ||
PKI-179 is an orally bioavailable dual inhibitor of PI3K and mammalian target of rapamycin (mTOR). In an in vitro enzymatic assay, it potently inhibits PI3K (IC50s = 8, 24, 17, and 74 nM for isoforms α, β, δ, and γ, respectively), two common PI3Kα mutants, E545K and H1047R (IC50s = 14 and 11 nM, respectively), and mTOR (IC50 = 0.42 nM). PKI-179 is selective for PI3K and mTOR over a panel of 361 other kinases at IC50 values up to 50 μM, hERG (IC50 > 30 μM), and cytochrome P450 (CYP) isoforms (IC5... |