Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38910 |
mGluR2 antagonist 1
|
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mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, with an IC50 value of 9 nM. Furthermore, it exhibits excellent permeability across the blood-brain barrier, making it a promising candidate for central nervous system-related studies or therapies. | |||
T3486 |
3-MATIDA
|
GluR; NMDAR | Neuroscience |
3-MATIDA 是一种有效的 mGluR-1 拮抗剂(IC50:6.3 μM,大鼠 mGluR-1a)。显示出 ≥ 40 倍于其他受体的选择性:mGluR-5、mGluR-2、mGluR-4 (mGluR-4a) (IC50 > 300 μM)、NMDA 和 GluR (AMPA) (IC50 = 250 μM)。 3-MATIDA 在体外培养的鼠皮质细胞和大鼠海马切片培养物中充当神经保护剂。 | |||
T5509 |
FPTQ
|
GluR | Neuroscience |
FPTQ,一种mGluR 1的高效拮抗剂,在人类和小鼠mGluR1上展示出6 nM和1.4 nM的IC50值[1]。除了其强大的抑制特性外,FPTQ在体外和体内实验中均表现出显著的抗氧化和抗炎效应[2]。 |