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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T13016	SR59230A	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	SR59230A 是可透过血脑屏障的、选择性的 β3-肾上腺素能受体拮抗剂，对 β3，β1 和 β2 受体的 IC50分别为 40、408 和 648 nM。
T72395	CB1 inverse agonist 2
	CB1inverse agonist 2 是一种口服有效的大麻素受体 CB1反向激动剂。CB1inverse agonist 2 在小鼠模型中，能有效抑制 CP55940 导致的体温失温和厌食情况。
T29206	ZCZ011 ZCZ 011,ZCZ-011
	ZCZ011 is a positive allosteric modulator of the cannabinoid CB1 receptor. ZCZ011 is brain penetrant, increased the potency of orthosteric agonists in mouse behavioral assays indicative of cannabimimetic activity, including antinociception, hypothermia, c
T28845	SR142948A HCl SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride
	SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concent
T38007	Noladin ether
	Noladin ether 是一种选择性的大麻素 CB1 受体激动剂（Ki=21.2 nM）。Noladin ether 可导致体温过低、肠道不动和轻度的缓解疼痛作用。
T38138	ACEA 2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide
	Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in ...
T73677	SR 142948 dihydrochloride
	SR 142948 dihydrochloride是一种口服活性高、选择性强的非肽类神经降压素受体(NT)拮抗剂，其在h-NTR1-CHO细胞、HT-29细胞和成年大鼠脑中IC50分别为1.19 nM、0.32 nM、3.96 nM。在HT-29细胞中，该化合物能够有效拮抗NT诱导的肌醇单磷酸盐形成，IC50为3.9 nM。此外，SR 142948 dihydrochloride在体内能够阻断NT诱导的体温下降、镇痛和转向行为，且具有良好的血脑屏障通透性，适用于精神疾病研究。

化合物

SR59230A

Cat.No: T13016

Synonym:

Target: Adrenergic Receptor

CB1 inverse agonist 2

Synonym: ZCZ 011,ZCZ-011

Target:

SR142948A HCl

Cat.No: T28845

Synonym: SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride

Synonym: 2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide

Target:

SR 142948 dihydrochloride

Cat.No: T73677

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T82407	Feruloyl tyramine
	Feruloyl tyramine 为一酰胺类化合物，可从大麻籽乙醇提取物中分离。在小鼠侧脑室注射该化合物，可引发体温降低及运动协调障碍。