Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7713 |
Benzyl nicotinate
烟酸苄酯,Rubriment,Pycaril |
GPR | Endocrinology/Hormones; GPCR/G Protein |
Benzyl nicotinate (Pycaril) 是血管扩张剂,可用于引起充血的一种活性成分。 | |||
T62036 |
Sovesudil
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Sovesudil (PHP-201) 是有效的、ATP 竞争性局部作用 Rho 激酶(ROCK)抑制剂。Sovesudil 抑制 ROCK I 和 ROCK II 的IC50分别为 3.7 和 2.3 nM。Sovesudil 可以降低眼压而不引起充血。 | |||
T71119 |
Netarsudil free base
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Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudi... |