4
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11337 |
Fumarate hydratase-IN-1
|
Others | Others |
Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor. | |||
T11336 | Fumarate hydratase-IN-2 sodium salt | Others | Others |
Fumarate hydratase-IN-2 sodium salt (compound 3) 是一种具有细胞渗透性和竞争性的富马酸水合酶(fumarate hydratase)抑制剂 (Ki=4.5 μM),具有营养依赖性细胞毒性。 | |||
T6759 |
AP-III-a4
ENOblock |
Glucokinase | Metabolism |
AP-III-a4 (ENOblock) 是第一个非底物类似物,可直接与烯醇酶结合,IC50=0.576 uM,可阻碍体内癌细胞转移。 | |||
T71901 |
MP-1
|
||
MP-1 is a covalent inhibitor of fumarate hydratase (FH) that exhibits cytotoxicity dependent on FH. MP-1 engages a functional cysteine in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5564 |
Tricarballylic acid
β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,三碳烯丙酸,Carballylic acid,Propane-1,2,3-tricarboxylic acid,丙三酸 |
aconitase; Mitochondrial Metabolism | Metabolism |
Tricarballylic acid (Carballylic acid) 是三碳烯丙酸酯的共轭酸,是一种乌头酸水合酶的竞争性抑制剂,其 Ki= 0.52 mM。 | |||
T4766 |
3-Methylglutaric acid
|
Endogenous Metabolite | Metabolism |
3-Methylglutaric acid 是亮氨酸代谢物,是一种与两种亮氨酸途径 HMGCL、AUH 酶缺陷显著相关的 C6 二元羧酸有机酸。 | |||
T78467 |
trans-10-Heptadecenoic acid
|
||
trans-10-Heptadecenoic acid 是一种能在特定酶作用下参与生物合成与代谢过程的反式脂肪酸。在 2,4-二烯酰基-CoA 还原酶与 Delta3,Delta2-烯酰基-CoA 异构酶催化下,trans-10-Heptadecenoic acid 可合成聚羟基链烷酸酯。当缺乏 2,4-二烯酰基-CoA 还原酶时,该化合物则经由多功能酶 (MFE) 中的烯酰辅酶 A 水合酶 II 进行降解。此外,trans-10-Heptadecenoic acid 能通过还原酶依赖性与直接 MFE 依赖性途径引起细胞内的碳外流。 |