Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5484 |
GSK467
|
Histone Demethylase; Histone Methyltransferase | Chromatin/Epigenetic |
GSK467 是一种有效的、选择性的 KDM5 (JARID1) 抑制剂,Ki 值为10 nM。 | |||
T76729 | Lucatumumab | ||
Lucatumumab (HCD122) 是一种全人抗 CD40拮抗剂单克隆抗体,可阻断 CD40/ CD40L 介导的信号通路。Lucatumumab 可有效介导抗体依赖性细胞介导的细胞毒性 (ADCC) 和肿瘤细胞清除,可用于顽固性淋巴瘤、慢性淋巴细胞白血病 (CLL) 和多发性骨髓瘤研究。 | |||
T71252 |
PC-046
|
||
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with di... | |||
T80919 |
Tumour-associated MUC1 epitope
|
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Tumour-associated MUC1 epitope是一种具有标志性的生物活性肽。作为高度糖基化的I型跨膜糖蛋白MUC1的一部分,该肽通过特定的胞外结构域展现,该结构域包含20个氨基酸组成的可变数量串联重复序列(VNTR)。在多种人类腺癌及血液恶性肿瘤(如多发性骨髓瘤和B细胞淋巴瘤)中细胞表面表达过量,因此,MUC1是许多免疫治疗策略的关键靶点。 |