Cat. No. | Product Name | Target | Signaling Pathways |
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T7683 |
Adenosine amine congener
ADAC |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Adenosine amine congener (ADAC) 是一种选择性的 A1 腺苷受体激动剂,具有神经保护作用,可以改善噪音和顺铂引起的耳蜗损伤。 | |||
T1812 |
KX1-004
KX1 004,KX1004 |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
KX1-004 是非 ATP 竞争性 Src-PTK 抑制剂,IC50=40 μM。它能够保护耳蜗,使其免受有害噪音的影响,并防止噪音引起的听力损失 (NIHL)。 | |||
T72224 | NK1 receptor antagonist 2 | ||
NK1receptor antagonist 2 是一种 NK1受体拮抗剂。NK1receptor antagonist 2 可用于耳鸣和听力损失的研究。 | |||
T33815 |
ORC-13661 HCl
ORC 13661,BPN13661,ORC13661,ORC-13661,BPN 13661,BPN-13661 |
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Orc-13661 (BNP-13661) is a potent and well-tolerated oral active protective agent for the prevention of aminogrogycoside-induced hearing loss. | |||
T61594 |
BF844
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BF844 is a chemical compound that demonstrates the ability to mitigate hearing loss in individuals with Usher Syndrome Type III (USH3) caused by the CLRN1 mutation (specifically N48K). One of its mechanisms of action is the transportation of CLRN1 N48K to the plasma membrane. In vivo studies have shown that BF844 significantly preserves hearing [1]. | |||
T78217 |
(R)-Azasetron besylate
SENS-401 |
Phosphatase | Metabolism |
(R)-Azasetron besylate (SENS-401)是一种口服活性的钙调神经磷酸酶抑制剂,能够减轻Cisplatin引发的听力损失和耳蜗损害。 | |||
T81664 |
NMB-1
|
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NMB-1,一种锥肽类似物,选择性抑制感觉神经元的持续机械激活电流(IC50: 1 μM),有效抑制机械性疼痛,并可用于研究听力和压力诱发疼痛。 | |||
T65440 | Sodium Thiosulfate Pentahydrate | ||
Sodium thiosulfate (Pentahydrate) is an antioxidant and antifungal. Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use[3]. The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival[4]. Calciphylaxis is a p... | |||
T80852 | VRT-534 | ||
VRT-534 针对连接蛋白 26 (Cx26)。在与重组WT Cx26及其突变体Cx26 K188N的结合中,VRT-534 显示出剂量依赖性,其EC50值分别为19 μM与5 μM。该化合物可应用于听力障碍的相关研究。 |