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Search Results for " galanin "

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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1732L	Galanin (1-30), human acetate 醋酸甘丙肽,Galanin (1-30), human acetate(119418-04-1 Free base)	Others	Others
	Galanin (1-30), human acetate (Galanin ) 是一种 30 个氨基酸的神经肽。它是 GalR1 和 GalR2 受体的激动剂，Kis 均为 1 nM。
TP1704	Galanin Receptor Ligand M35 TFA	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galanin Receptor Ligand M35 TFA(142846-71-7 free base) 是一种高亲和力配体和甘丙肽受体拮抗剂 (Kd=0.1 nM)。
TP1380	Galanin (1-16), mouse, porcine, rat	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galanin (1-16), mouse, porcine, rat 是一种有效的甘丙肽受体激动剂，Kd 为 3 nM。
T37718	Galanin (rat, mouse) (trifluoroacetate salt) GAL (rat, mouse),Galanin (rat, mouse) (trifluoroacetate salt)
	Galanin is a neuropeptide with diverse biological activities. [1][2][3][4][5] It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively). [1] Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol . [2] In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and...
TP2028	Galanin (1-29)(rat, mouse) Galanin (1-29) (rat, mouse)
	Non-selective galanin receptor agonist (Ki values are 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively). Anticonvulsant; prevents the occurrence of full kindled seizures in rats.
T38110	Galanin (Human) (Acetate)
	Galanin (Human) (Acetate)是一种含有30个氨基酸的神经肽和丙氨酸(GAL)受体激动剂。在表达重组人gal1受体的HEK293E 细胞(EC50= 0.031 nM)中，它抑制佛司可林诱导的cAMP 产生，并刺激表达重组人gal2受体的CHO 细胞(EC50= 12.3 nM)中肌醇磷酸的积累。Galanin (Human) (Acetate)诱导离体大鼠纵向眼底收缩，ec50值为13.8 nM。在大鼠福尔马林试验的第二阶段，鞘内给药人甘丙肽(3、10和30 nmol/只)可减少大鼠舔爪和退缩。
TP1662	Galanin Receptor Ligand M35
	The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and perf
TP2251	Galanin (2-29) (rat)	Others	Others
	Peptide agonist for galanin receptors
TP1529	Galanin (1-19), human
	Galanin (1-19), human, represents the fragment encompassing amino acids 1 to 19 of the human galanin neuropeptide. Galanin (GAL) is known for its extensive distribution and multifaceted biological roles, such as regulating hormone secretion, providing antinociceptive effects, and altering feeding behavior.
TP1732	Galanin (1-30), human
	Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM. Endogenous peptide with multiple endocrine, metabolic and behavioral effects. Has been shown to have an action on intestinal
TP2250	Galanin (1-15) (porcine, rat)	Others	Others
	N-terminal galanin fragment used to mediate central cardiovascular effects
T38109	Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
	Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the GAL2receptor (IC50= 1.76 nM for the rat receptor) over the GAL1receptor (IC50= 879 nM for the human receptor) but does also bind to the GAL3receptor (Ki= 271 nM for the rat receptor).1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobi...
TP1317	Galanin (1-16), mouse, porcine, rat TFA
	Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM. Galanin (1-16), mouse, porcine, rat shows high biological activity on locus coeruleus neurons.
T82345	Galanin-B2 NAX-5055
	Galanin-B2 在癫痫模型中表现出活性，并能穿透血脑屏障。
T80516	human GALP (3-32) Galanin-like peptide (3-32)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Human GALP (3-32) (Galanin-like peptide (3-32)) 是一种高效的galanin receptor激动剂。在竞争性结合实验中，该化合物对GalR1 (IC50=33 nM) 及GalR2 (IC50=15 nM) 表现出强烈亲和力。此外，human GALP (3-32) 显著增加了转染GalR2 (EC50=360 nM) 的 SH-SY5Y细胞的胞外酸化速率。
T80146	Galanin-Like Peptide (rat)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galanin-Like Peptide (rat) 是含60个氨基酸的神经肽，主要功能是调节摄食、体重及能量代谢。
T80144	Galanin-Like Peptide (human)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galanin-Like Peptide (human) 是由60个氨基酸组成的神经肽，在调节摄食、体重和能量代谢方面具有重要功能。
T80145	Galanin-Like Peptide (porcine)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galanin-Like Peptide (porcine) 是由60个氨基酸组成的神经肽，原始分离自猪下丘脑。这一肽类对GALR2受体表现出高度亲和力（IC50为0.24 nM），而对GALR1受体则表现出较低的亲和性（IC50为4.3 nM）。
T80517	Ala5-Galanin (2-11)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Ala5-Galanin(2-11)为特异性丙氨酸受体2(GAL2R)激动剂，其Ki值为258 nM。
T75818	Galanin (1-29)(rat, mouse) TFA
	Galanin(1-29)(rat, mouse) TFA 是一种非选择性甘丙肽受体 (galaninreceptor) 激动剂，对 GAL1、GAL2 和 GAL3 的Ki 值分别为 0.98、1.48 和 1.47 nM。具有抗惊厥作用。
T82346	Galanin message associated peptide (1-41) amide
	Galanin message-associated peptide (1-41) amide 是肽类激素，结构由41个氨基酸残基组成，并以酰胺形式存在。
T80143	Galanin (1-13)-Neuropeptide Y (25-36) amide	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galanin(1-13)-Neuropeptide Y (25-36) amide 是一种兼具高亲和力的甘丙肽受体和甘丙肽之配体。
T8456	GALNON	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galnon 是一种甘丙肽受体激动剂，可改善内在的皮质骨组织特性。
T8963	CYM2503	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	CYM2503 是 GAL2 受体的正变构调节剂 (PAM)，可在体外增强甘丙肽诱导的 IP1 产生。它对受体的正构甘丙肽结合位点没有亲和力（通过其无法置换碘化甘丙肽或自行诱导 IP1 积累来衡量）。
T15368L	Galantide acetate Galantide acetate(138579-66-5 Free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galantide acetate 是一种特殊的甘丙肽受体 (galanin receptor) 拮抗剂，是一种由甘丙肽和 P 物质片段组成的肽段，在大鼠下丘脑可识别两类甘丙肽结合位点 (KD 分别小于 0.1 nM 和 ~6 nM)。Galantide 剂量依赖性 (IC50=1.0 nM) 拮抗甘丙肽介导的葡萄糖诱导的小鼠胰岛胰岛素分泌抑制。Galantide acetate 似乎与单一的 SP 受体群结合 (KD~40 nM)。
TP1992L	M40 acetate(143896-17-7 free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	M40 acetate(143896-17-7 free base) 是一种有效的、非选择性的甘丙肽受体拮抗剂（GAL1 和 GAL2 的 Ki 值分别为 1.82 和 5.1 nM），在体外抑制大鼠脑中甘丙肽 (1-29) 的结合 (IC50 = 3 - 15 nM)。减弱氟西汀的抗抑郁作用并阻止甘丙肽诱导的体内食物摄入。在剂量 > 100 nM 时，对外周 GAL2 受体也表现出较弱的部分激动剂活性。
T5455	HT-2157 SNAP37889,SNAP-37889	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	HT-2157 (SNAP-37889) 是一种高亲和力、选择性和竞争性的甘丙肽 3 受体 (Gal3) 拮抗剂。
TP1991L	M 1145 acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	M1145 acetate 是一种嵌合肽，是一种选择性甘丙肽受体 2 (GAL2) 激动剂，Ki 为 6.55 nM。它对 GAL2 的亲和力比 GAL1 高 90 倍以上（Ki=587 nM），比 GalR3 的亲和力高 76 倍（Ki=497 nM）。它对甘丙肽的信号转导具有累加作用。
T8559	Galnon TFA(475115-35-6(free base))	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	GALNON TFA(475115-35-6(free base)) 是一种新型非肽甘丙肽受体激动剂（GAL1 和 GAL2，Ki 分别为 11.7 和 34.1 μM）。
TP1930L1	Spexin acetate(1370290-58-6 free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Spexin acetate(1370290-58-6 free base) 是一种有效的甘丙肽受体 2/3 (GAL2/GAL3) 激动剂（EC50 值分别为 45.7 和 112.2 nM）。对甘丙肽受体 1 没有显着的活性。抑制脂肪细胞对长链脂肪酸的摄取并减少饮食诱导的肥胖小鼠和大鼠的食物消耗。减少金鱼的 LH 分泌。在体内表现出抗焦虑作用。
TP1994L	M871 acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	M871 acetate 是一种选择性甘丙肽 GAL2 受体拮抗剂（对 GAL2 和 GAL1 受体的 Ki 值分别为 13.1 和 420 nM）。它阻断包括 AR-M1896 在内的 GAL2 激动剂的伤害感受作用。
TP1993L	M617 acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	M617 acetate 是甘丙肽受体 1 (GAL1) 的选择性激动剂。 M617 acetate 通过中枢 GAL1 起作用，促进 GLUT4 表达，并提高 2 型糖尿病大鼠心肌中的 GLUT4 含量。 GAL1 和 GAL2 的 Ki 值分别为 0.23 和 5.71 nM。
T15368	Galantide	Others	Others
	Galantide is a reversible and non-specific antagonist of galanin receptor.
T28822	SNAP 398299 SNAP-398299,SNAP398299
	SNAP 398299, a galanin receptor antagonist, is a potential novel pharmacological treatment for mood disorders.
TP1991	M1145 M 1145
	Potent and selective galanin receptor 2 (GAL2) agonist (EC50 = 38 nM, Ki values are 6.55, 497 and 587 nM at GAL2, GAL3 and GAL1 respectively). Has an additive effect on the signal transduction of galanin.
TP1992	M40
	Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
T75749	Galantide TFA
	Galantide TFA 是一种可逆的非特异性甘丙肽 galanin(GAL)受体拮抗剂。Galantide TFA 剂量依赖性显示出对 galanin 诱导的 K+电导的拮抗作用，IC50值为 4 nM。Galantide TFA 可用于神经疾病和激素代谢的研究。
T76002	Spexin TFA
	Spexin TFA, a potent agonist for galanin receptor 2/3 (GAL2/GAL3) with EC50 values of 45.7 and 112.2 nM respectively, shows no significant activity towards galanin receptor 1. As an endogenous peptide promoting satiety, it reduces long chain fatty acid uptake by adipocytes and lowers food consumption in diet-induced obese mice and rats. Additionally, it moderates LH secretion in goldfish and demonstrates anxiolytic effects in vivo.
TP1930	Spexin
	Potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreas
TP1993	M617
	Selective galanin GAL1 receptor agonist (Ki values are 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.
TP1849	Transportan
	Transportan is a 27 amino acid-long peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine.
TP1994	M871
	Selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM for GAL2 and GAL1 receptors respectively). Blocks the pro-nociceptive effect of GAL2 receptor agonists.
T83148	Alarin (human)
	Alarin (human) 属于下丘脑甘丙肽家族，包含 GALP 前体肽的信号序列和成熟 GALP 前 5 个氨基酸。
T75819	M1145 TFA
	M1145是一种选择性GAL2甘丙肽受体激动剂，具有6.55 nM的Ki值。与GAL1（Ki=587 nM）相比，M1145对GAL2的亲和力提高了90倍以上；与GAL3（Ki=497 nM）相比，其亲和力增加了76倍。M1145对于甘丙肽信号转导展现出加性效应。
T73648	Galnon TFA
	Galnon TFA 是一种选择性的非肽类的甘丙肽GAL1和GAL2受体激动剂，其Ki 值分别为 11.7 和 34.1 μM。Galnon TFA 具有抗惊厥和抗焦虑作用。
T75817	M617 TFA
	M617 TFA 是一种选择性甘丙肽受体 1(GAL1)激动剂，对 GAL1 和 GAL2 的 Ki 分别为 0.23 和 5.71 nM。M617 TFA 通过其中枢 GAL1 作用，促进 2 型糖尿病大鼠心肌 GLUT4的表达，提高 GLUT4的含量。

化合物

Galanin (1-30), human acetate

Cat.No: TP1732L

Synonym: 醋酸甘丙肽,Galanin (1-30), human acetate(119418-04-1 Free base)

Target: Others

Galanin Receptor Ligand M35 TFA

Cat.No: TP1704

Target: Neuropeptide Y Receptor

Galanin (1-16), mouse, porcine, rat

Cat.No: TP1380

Target: Neuropeptide Y Receptor

Galanin (rat, mouse) (trifluoroacetate salt)

Cat.No: T37718

Synonym: GAL (rat, mouse),Galanin (rat, mouse) (trifluoroacetate salt)

Galanin (1-29)(rat, mouse)

Cat.No: TP2028

Synonym: Galanin (1-29) (rat, mouse)

Galanin (Human) (Acetate)

Cat.No: T38110

Galanin Receptor Ligand M35

Cat.No: TP1662

Galanin (2-29) (rat)

Cat.No: TP2251

Target: Others

Galanin (1-19), human

Cat.No: TP1529

Galanin (1-30), human

Cat.No: TP1732

Galanin (1-15) (porcine, rat)

Cat.No: TP2250

Target: Others

Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Cat.No: T38109

Galanin (1-16), mouse, porcine, rat TFA

Cat.No: TP1317

Cat.No: T82345

Synonym: NAX-5055

human GALP (3-32)

Cat.No: T80516

Synonym: Galanin-like peptide (3-32)

Target: Neuropeptide Y Receptor

Galanin-Like Peptide (rat)

Cat.No: T80146

Target: Neuropeptide Y Receptor

Galanin-Like Peptide (human)

Cat.No: T80144

Target: Neuropeptide Y Receptor

Galanin-Like Peptide (porcine)

Cat.No: T80145

Target: Neuropeptide Y Receptor

Ala5-Galanin (2-11)

Cat.No: T80517

Target: Neuropeptide Y Receptor

Galanin (1-29)(rat, mouse) TFA

Cat.No: T75818

Galanin message associated peptide (1-41) amide

Cat.No: T82346

Galanin (1-13)-Neuropeptide Y (25-36) amide

Cat.No: T80143

Target: Neuropeptide Y Receptor

Cat.No: T8456

Target: Neuropeptide Y Receptor

Cat.No: T8963

Target: Neuropeptide Y Receptor

Galantide acetate

Cat.No: T15368L

Synonym: Galantide acetate(138579-66-5 Free base)

Target: Neuropeptide Y Receptor

M40 acetate(143896-17-7 free base)

Cat.No: TP1992L

Target: Neuropeptide Y Receptor

Cat.No: T5455

Synonym: SNAP37889,SNAP-37889

Target: Neuropeptide Y Receptor

Cat.No: TP1991L

Target: Neuropeptide Y Receptor

Galnon TFA(475115-35-6(free base))

Cat.No: T8559

Target: Neuropeptide Y Receptor

Spexin acetate(1370290-58-6 free base)

Cat.No: TP1930L1

Target: Neuropeptide Y Receptor

Cat.No: TP1994L

Target: Neuropeptide Y Receptor

Cat.No: TP1993L

Target: Neuropeptide Y Receptor

Cat.No: T15368

Target: Others

Cat.No: T28822

Synonym: SNAP-398299,SNAP398299

Cat.No: TP1991

Synonym: M 1145

Cat.No: TP1992

Cat.No: T75749

Cat.No: T76002

Cat.No: TP1930

Cat.No: TP1993

Cat.No: TP1849

Cat.No: TP1994

Cat.No: T83148

Cat.No: T75819

Cat.No: T73648

Cat.No: T75817

Cat. No.	Product Name	Target	Signaling Pathways
TJS0341	7-Amino-4-(trifluoromethyl)coumarin 香豆素151,Coumarin 151,AFC,7-氨基-4-（三氟甲基）香豆素	5-HT Receptor	GPCR/G Protein; Neuroscience
	7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) 是一种荧光标记物，其激发和发射波长分别为400和500 nm，可用来灵敏的检测蛋白酶。

天然产物

7-Amino-4-(trifluoromethyl)coumarin

Cat.No: TJS0341

Synonym: 香豆素151,Coumarin 151,AFC,7-氨基-4-（三氟甲基）香豆素

Target: 5-HT Receptor

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