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Search Results for " furin "

15

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7495	Hexa-D-arginine	Others	Others
	Hexa-D-arginine 是稳定的furin 抑制剂，能够作用于 furin (Ki:106 nM)、PACE4 (Ki:580 nM)、PC1 (Ki:13.2 nM)。它在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。
TP1160	Hexa-D-arginine TFA Furin Inhibitor II TFA
	Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
T9964	BOS-318	Others	Others
	BOS-318是一种Furin 抑制剂，具有缓慢解离，高选择性，细胞通透性等特点。
T40686	Tiazofurin NSC 286193,Riboxamide,噻唑呋林	Dehydrogenase	Metabolism
	Tiazofurin (NSC-286193) 是一种合成的核苷类似物，显示出抗肿瘤活性。它在细胞内合成为 tiazole-4-carboxamide adenine dinucleotide (TAD)，TAD 可有效抑制 IMP 脱氢酶。
T16690	Pyrazofurin	Others	Others
	Pyrazofurin is a pyrimidine nucleoside analogue, inhibits cell proliferation and DNA synthesis in cells by inhibiting UMP synthase. Pyrazofurin is a sensitive orotate-phosphoribosyltransferase inhibitor (IC50s between 0.06-0.37 µM in the cell lines Hep-2,
T28744	Selenazofurin BRN 4198668,CI-935,CI 935,CI935
	Selenazofurin is an antiviral compound. Selenazofurin inhibits the cytopathic effect and yield of influenza A/NWS/33 virus with 50% effective dose ranges of 0.7 to 1.4 micrograms/ml.
T30002	Ammifurin
	Ammifurin is a Furocoumarin mixture used in treatment of vitiligo.
T78121	SSM3 tetraTFA hydrate	Others	Others
	SSM3 tetraTFA hydrate为有效的furin抑制剂，具有54 nM的EC50和12 nM的Ki。该化合物可有效阻断furin依赖的炭疽毒素保护antigen-83在细胞表面的处理。
T69640	MI-1851
	MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells.
T68339	SSM3 TFA
	SSM3 TFA is a potent furin inhibitor, blocking furin-dependent cell surface processing of anthrax protective antigen-83 in vitro..
T41178	SSM 3 trifluoroacetate
	SSM 3 trifluoroacetate is a potent furin inhibitor (EC50= 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83in vitro.
T76607	Boc-Arg-Val-Arg-Arg-AMC hydrochloride
	Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) 是一种合成的荧光底物，可被furin 蛋白酶有效裂解。
TP2038	Decanoyl-RVKR-CMK
	Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in
T82592	DEC-RVRK-CMK Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
	DEC-RVRK-CMK为一种小型合成抗病毒化合物，具不可逆性及细胞渗透性，作为竞争性弗林蛋白酶抑制剂，该化合物对寨卡病毒(ZIKV)和日本脑炎病毒(JEV)显示出显著的抗病毒活性。
T78224	Histatin-3
	Histatin-3是一肽类物质，由32个氨基酸残基构成，表现出显著的抗菌活性。作为前蛋白转化酶1(PC1)的底物，Histatin-3在Arg25位点的羧基端被该蛋白酶特异性切割（HRGYR降低SN）。此外，Histatin-3亦作为中等效力的、可逆的以及具竞争性的抑制剂，能够抑制弗林蛋白酶介导的五肽pGlu-Arg-Thr-Lys-Arg-MCA荧光底物的裂解，其抑制常数Ki大约为1.98μM。

化合物

Hexa-D-arginine

Cat.No: T7495

Target: Others

Hexa-D-arginine TFA

Cat.No: TP1160

Synonym: Furin Inhibitor II TFA

Cat.No: T9964

Target: Others

Cat.No: T40686

Synonym: NSC 286193,Riboxamide,噻唑呋林

Target: Dehydrogenase

Cat.No: T16690

Target: Others

Cat.No: T28744

Synonym: BRN 4198668,CI-935,CI 935,CI935

Cat.No: T30002

SSM3 tetraTFA hydrate

Cat.No: T78121

Target: Others

Cat.No: T69640

Cat.No: T68339

SSM 3 trifluoroacetate

Cat.No: T41178

Boc-Arg-Val-Arg-Arg-AMC hydrochloride

Cat.No: T76607

Decanoyl-RVKR-CMK

Cat.No: TP2038

Cat.No: T82592

Synonym: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone

Cat.No: T78224

Cat. No.	Product Name	Target	Signaling Pathways
T70221	Dibefurin
	Dibefurin is a metabolite that inhibits the activity of calcineurin, a calcium/calmodulin-dependent protein phosphatase involved in the activation of T lymphocytes.

天然产物

Cat.No: T70221

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