Cat. No. | Product Name | Target | Signaling Pathways |
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T11005 |
Desmethyl Celecoxib
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COX | Immunology/Inflammation; Neuroscience |
Desmethyl Celecoxib 是一种选择性的环氧化酶 2 (COX-2) 抑制剂,IC50为 32 nM,具有抗炎活性。 | |||
T4565 |
Tafamidis
他发米帝司甲葡胺,氯苯唑酸,Fx-1006A |
Others | Others |
Tafamidis (Fx-1006A) 是选择性的transthyretin (TTR)稳定剂,对野生型 WT-TTR 、突变型同源四聚体 V30M-TTR、V122I-TTR 的活性相当,它们的EC50值为2.7-3.2 μM。它对淀粉样蛋白的生成具有抑制作用。 | |||
T26182 |
Seladelpar lysine
MBX-8025 lysine dihydrate,MBX-8025 Lysine,MBX 8025 Lysine MBX8025 Lysine |
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Seladelpar lysine, a selective PPAR-δ agonist, is used for the therapy of Homozygous Familial Hypercholesterolemia (HoFH). | |||
T39492 |
FRM-024
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FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease. | |||
T61430 | S-2E | ||
S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2]. | |||
T74720 |
Mipomersen
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Mipomersen (ISIS 301012 free base) 是载脂蛋白 B(apoB)的反义寡核苷酸抑制剂。Mipomersen 具有抗HCV 的作用,可降低HCV 的感染性。Mipomersen 可用于纯合子家族性高胆固醇血症 (HoFH) 的研究。 | |||
T78807 | YIAD-0205 | ||
YIAD-0205为口服有效的Aβ(1-42)聚集抑制剂,在5XFAD AD转基因小鼠模型中展现体内效力。 | |||
T36059 |
Dichlorphenamide-13C6
Dichlorphenamide-13C6 |
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Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induc... | |||
T36499 |
CuATSM
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The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Mutations in SOD1, which alter its metal binding capacity and can result in protein misfolding and aggregation, have been linked to familial amyotrophic lateral sclerosis (ALS). Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that has traditionally been used in cellular imaging experiments to selectively label hypoxic tissue via its susceptibility ... |