Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11120 |
Duocarmycin TM
|
DNA Alkylation; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Duocarmycin TM 是一种有抗肿瘤活性的抗生素,也是一种 DNA 烷化剂。 | |||
T23133 |
Pentamidine
|
Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal | Metabolism; Microbiology/Virology |
Pentamidine 是抗微生物剂,会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究,有抗肿瘤活性,抗菌活性。 | |||
T11118 |
Duocarmycin SA
|
Others | Others |
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro. | |||
T11338 |
Furamidine
DB75,NSC 305831 |
Others | Others |
Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and ... | |||
T81640 |
NSC15520
|
||
NSC15520是一种小分子RPA抑制剂,特异性结合RPA的N端DNA结合域(DBD),阻断其与p53或RAD9的相互作用。它还能够抑制双链DNA(dsDNA)寡核苷酸的螺旋不稳定性,影响DNA复制、修复、重组及损伤反应信号。 | |||
T37218 |
N-methyl Mesoporphyrin IX
|
||
N-methyl Mesoporphyrin IX 是广泛使用的 G-quadruplex DNA 特异性荧光结合剂,能有效监测 Aβ 纤颤。N-methyl Mesoporphyrin IX 对 G-四链体 DNA 敏感,对双链体、三链体和单链形式的 DNA 没有反应。N-methyl Mesoporphyrin IX 需通过与 Aβ 组装体堆叠才能发出强荧光。同时 N-methyl Mesoporphyrin IX 是一种原位抑制剂,是体外和细胞内 Aβ 淀粉样蛋白生成的非原位监测器。 |