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Cat. No.	Product Name	Target	Signaling Pathways
T36253	dTAGV-1
	Degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand. Induces potent and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. Selectively degrades FKBP12F36V-EWS/FLI fusion proteins and inhibits cell proliferation in FKBP12F36V-EWS/FLI-expressing Ewing sarcoma cells. Hydrochloride salt (Cat.No. 7374) available; suitable for in vivo use. Negative control...
T36254	dTAGV-1 hydrochloride
	Hydrochloride salt of dTAGV-1. Suitable for use in vivo. Following ip administration of 10 mg/kg in mice: T = 4.43 h; Cmax = 2123 ng mL-1; AUCinf = 18517 hrng mL-1 and CL = 9.05 mL min-1 kg-1 Negative control dTAGV*-1-NEG also available. Important: It is recommended that DMSO stock solutions of this compound are made and used on the same day and are not subjected to freeze/thaw.
T40251	dTAGV-1 TFA	PROTACs	PROTAC
	dTAGV-1 TFA is a highly effective and specific compound that targets mutant FKBP12 F36V fusion proteins for degradation. It possesses potent activity in inducing the degradation of the FKBP12 F36V -Nluc protein in living organisms.
T36255	dTAGV-1-NEG
	Negative control for dTAGV-1.
T74412	dTAGV-1-NEG TFA
	dTAGV-1-NEG TFA 是一种非对映异构体，是 dTAGV-1 的异双功能阴性对照。dTAGV-1-NEG TFA 是一种 FKBP12F36V 选择性降解剂。