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Cat. No. | Product Name | Target | Signaling Pathways |
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T3978 |
Linerixibat
GSK2330672,Iinerixibat |
HBV | Microbiology/Virology |
Linerixibat (GSK2330672) 是高效的、不可吸收的、具有口服活性的顶端钠依赖性胆汁酸转运蛋白 (ASBT) 抑制剂,对人ASBT 的IC50为 42 nM。它是一种降脂剂,具有用于 2 型糖尿病和原发性胆源性胆管炎的研究潜力。 | |||
T64334 |
Glycolithocholic acid, sodium salt
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Others | Others |
Glycolithocholic acid, sodium salt 是 Glycolithocholic acid 的钠盐。Glycolithocholic acid 是一种甘氨酸结合的次级胆汁酸。Glycolithocholic acid 可用于诊断溃疡性结肠炎 (UC),非酒精性脂肪性肝炎 (NASH0) 和原发性硬化性胆管炎 (PSC)。 | |||
T76700 |
Simtuzumab
GS 6624,AB 0024 |
Monoamine Oxidase | Neuroscience |
Simtuzumab 是一种针对赖氨酰氧化酶样蛋白 2 (LOXL2) 的单克隆抗体。Simtuzumab 可用于治疗原发性硬化性胆管炎 (PSC),对非酒精性脂肪性肝炎引起的桥接性纤维化或代偿性肝硬化患者无效 。 | |||
T10087 |
24-Norursodeoxycholic acid
nor-UDCA |
Others | Others |
24-Norursodeoxycholic acid (nor-UDCA) 是一种侧链缩短的 UDCA 的 C23 同系物,表现出有效的抗胆汁淤积,抗炎和抗纤维化活性。 | |||
T6582L |
Mezlocillin
Bay-f 1353,Meslocillin,Melocin,Baypen,Mezlin |
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Meloxicillin is a broad-spectrum penicillin antibiotic that is active against both Gram-negative bacteria and some Gram-positive bacteria. Unlike most other broad-spectrum penicillin, it is excreted by the liver and can therefore be used to treat biliary | |||
T69517 |
Bexotegrast HCl
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Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts. | |||
T73155 |
BMS-986339
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BMS-986339 是一种具有口服活性的FXR 激动剂。BMS-986339 可与 His298 和 ASN287 残基形成氢键。BMS-986339 可用于原发性胆汁性肝硬化 (PBC)、原发性硬化性胆管炎 (PSC)、非酒精性脂肪性肝炎 (NASH),和抗纤维化研究。 | |||
T73414 | EDP-305 | ||
EDP-305是一种具有选择性的口服farnesoid X受体(FXR)激动剂,其EC50值分别为34 nM(CHO细胞嵌合性FXR)和8 nM(HEK细胞全长FXR)。该化合物展现了强大且持久的抗纤维化效果,并适用于原发性胆道胆管炎(PBC)与非酒精性脂肪性肝炎(NASH)的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T31964 |
Glycolithocholic acid
Lithocholic acid glycine conjugate,甘氨石胆酸,Lithocholylglycine |
Others | Others |
Glycolithocholic acid (Lithocholic acid glycine conjugate) 属于内源性代谢产物,是甘氨酸结合的次级胆汁酸。它可用于诊断非酒精性脂肪性肝炎,溃疡性结肠炎和原发性硬化性胆管炎。 |