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Cat. No. | Product Name | Target | Signaling Pathways |
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T7198 |
E-4031
(1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇 |
EGFR; Potassium Channel | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
E-4031是甲磺酰苯胺III 类抗心律失常药,选择性地阻断hERG 钾通道。 | |||
T6476 |
Dofetilide
UK 68789,UK-68798,Tikosyn,多非利特 |
Potassium Channel | Membrane transporter/Ion channel |
Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂,作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。 | |||
T71122 |
Carsatrin (free base)
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Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin | |||
T70975 |
Carsatrin succinate
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Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbi... | |||
T26751 |
BBR 2160
BBR-2160,BBR2160 |
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BBR 2160 is a dihydropyridine derivative belonging to the group of the so-called tiampidine. BBR 2160 has calcium-antagonistic properties in cardiac tissue. Intracellular microelectrodes have been used to characterize the electrophysiological properties o |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3S0081 |
Oxypeucedanin
(+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin |
Potassium Channel | Membrane transporter/Ion channel |
Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物,分离自Angelica dahurica。它是选择性开放通道阻滞剂,可抑制hKv1.5通道电流,IC50值为 76 nM。它延长心脏动作电位持续时间,是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。 |