Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21773 |
SP-141
SP 141 |
Mdm2 | Apoptosis |
SP-141 是一种 MDM2 抑制剂,可促进 MDM2 自身泛素化和降解,具有抗癌活性。 | |||
T73560 |
I-138
|
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
I-138 是一种具有口服活性和有效性的 USP1-UAF1 可逆抑制剂。I-138 促使细胞中 FANCD2 和 PCNA 的单泛素化,抑制细胞中的 USP1 自裂解。 | |||
T69701 |
HS-152
|
||
HS-152 is a novel reversible inhibitor of smurf1, directly targeting the catalytic activity of smurf hect domains, significantly blocking auto-ubiquitination and the transfer of ubiquitin from hect domain to the substrates to form isopeptide bond |