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Search Results for " antiestrogen "

11

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12148	N-Desmethyltamoxifen hydrochloride	Estrogen Receptor/ERR; Endogenous Metabolite; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
	N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内主要的三苯氧胺代谢物。它是蛋白激酶 C 抑制剂，也是人体 AML 细胞神经酰胺代谢的有效调节因子，可限制神经酰胺糖基化、水解和鞘氨醇磷酸化。
T60115	EM-651 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2R)-
	EM-651 (2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2R)-)是EM-652的一种活性较低的对映体，IC50=20.0 nM。EM-652是一种口服有效的、选择性的雌激素受体拮抗剂，IC50=0.44nM。
T26295	Trioxifene mesylate LY 133314,LY-133314,LY133314
	Trioxifene mesylate is an antiestrogen that suppresses growth hormone secretion.
T25262	Clometherone Lilly 38000,Lilly38000,Clometeron,Lilly-38000
	Clometherone is a synthetic pregnane steroid and derivative of progesterone which is used as an antiestrogen and antiandrogen.
T15452	GW7604	Others	Others
	GW7604 is an antiestrogen and it also is the metabolite of GW5638. GW5638 is an antagonist of high-affinity estrogen receptor (ER).
T23737	Anordiol H 241,H241,AF-45,AF 45,AF45
	Anordiol is an antiestrogen with estrogenic activity. It also is known to inhibit fertility.
T40166	Bexirestrant
	Bexirestrant is an orally active ER-α degrader commonly employed in the research of antiestrogen and antineoplastic therapies.
T23273	RU 58668	Others	Others
	Pure antiestrogen that downregulates estrogen receptor expression
T12312	OP-1074	Estrogen/progestogen Receptor	Endocrinology/Hormones
	OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
T72945	Palazestrant
	Palazestrant为一抗雌激素及抗肿瘤试剂，与HER2抑制剂联合应用，有效抑制ER+/HER2+癌症。
T70013	Pipendoxifene
	Pipendoxifene, also known as ERA-923, is a new antiestrogen with potential anticancer activity. ERA-923 potently inhibits estrogen binding to ER-alpha (IC50 = 14 nM). In ER-alpha-positive human MCF-7 breast carcinoma cells, ERA-923 inhibits estrogen-stimulated growth (IC50 = 0.2 nM) associated with cytostasis. In vitro, a MCF-7 variant with inherent resistance to tamoxifen (10-fold) or 4-OH tamoxifen (>1000-fold) retains complete sensitivity to ERA-923 . In preclinical models, ERA-923 has an imp...

化合物

N-Desmethyltamoxifen hydrochloride

Cat.No: T12148

Target: Estrogen Receptor/ERR, Endogenous Metabolite, PKC

Cat.No: T60115

Synonym: 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2R)-

Trioxifene mesylate

Cat.No: T26295

Synonym: LY 133314,LY-133314,LY133314

Cat.No: T25262

Synonym: Lilly 38000,Lilly38000,Clometeron,Lilly-38000

Cat.No: T15452

Target: Others

Cat.No: T23737

Synonym: H 241,H241,AF-45,AF 45,AF45

Cat.No: T40166

Cat.No: T23273

Target: Others

Cat.No: T12312

Target: Estrogen/progestogen Receptor

Cat.No: T72945

Cat.No: T70013

Cat. No.	Product Name	Target	Signaling Pathways
TN4731	Pachyaximine A	Antifection	Microbiology/Virology
	Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS
TN3472	Axillaridine A	Others	Others
	Axillaridine A is a new cholinesterase inhibitors, it may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimer's disease patients by potentiating and

天然产物

Cat.No: TN4731

Target: Antifection

Cat.No: TN3472

Target: Others

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