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Cat. No. | Product Name | Target | Signaling Pathways |
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T21294 |
Polmacoxib
CG-100649,帕马考昔,CG100649,CG 100649 |
COX; Carbonic Anhydrase | Immunology/Inflammation; Metabolism; Neuroscience |
Polmacoxib (CG 100649) 是一流的 NSAID 候选药物,是碳酸酐酶 (CA) 和 COX-2 的双重抑制剂。它在小鼠模型中抑制大肠腺瘤和肿瘤生长。 | |||
T8359 |
Lanreotide acetate
Lanreotide acetate (108736-35-2 free base),BIM 23014 (acetate),BIM 23014 acetate |
Others | Others |
Lanreotide acetate (BIM 23014 acetate) 是生长抑素类似物,具有抗肿瘤活性,可用于类癌综合症。 | |||
T41179 |
CL 82198 hydrochloride
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CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibitsin vitroinvasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish. | |||
T74815 | SLC26A3-IN-2 | ||
SLC26A3-IN-2 是一种口服有效的阴离子交换蛋白 SLC26A3的抑制剂 (IC50=360 nM)。SLC26A3 属于溶质载体 (SLC) 蛋白,属于 SLC26 家族。SLC26 家族对氯化物、碳酸氢盐、硫酸盐和草酸盐具有广泛的阴离子特异性。SLC26A3 在腺瘤 (DRA) 中下调,参与氯化物和草酸盐的肠道吸收。SLC26A3 功能突变的丧失与氯离子丢失性腹泻有关。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0193 |
N2,N2-Dimethylguanosine
N2,N2-二甲基鸟苷 |
Endogenous Metabolite | Metabolism |
N2,N2-Dimethylguanosine 是尿核苷,是 tRNA 的初级代谢产物。 | |||
T36472 |
Tetrahydro-11-deoxy Cortisol
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Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA. |