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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2212L	a-MSH, amide Acetate(581-05-5 free base)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	a-MSH, amide Acetate(581-05-5 free base) 是一种内源性黑皮质素受体 4 (MC4R) 激动剂，具有抗炎和解热活性。 α-MSH 是阿片黑皮质素原 (POMC) 的翻译后衍生物。
T7813	α-MSH MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide	Melanocortin Receptor; Adenylyl cyclase	GPCR/G Protein; Neuroscience
	α-MSH (MSH, amide) 是一种内源性神经肽，是一种内源性黑皮质素受体 4 (MC4R) 激动剂，具有抗炎和解热活性。
TP2212	a-MSH, amide	Others	Others
	a-MSH, amide is a peptide with the sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, MW= 1664.9. The melanocyte-stimulating hormones (collectively referred to as MSH or intermedins) are a class of peptide hormones that are produced by c
TP1097	Melanotan I 美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I	Others	Others
	Melanotan I 是一种非特异性黑素皮质激素受体 (MCR) 激动剂，是一种 α- 黑素细胞刺激激素 (α-MSH) 类似物，皮下注射可增加黑色素在皮肤中的含量。Melanotan I 可用于辅助美黑。Melanotan I 可用于预防阳光诱发皮肤癌，可用于研究黑色素瘤和男性勃起功能障碍。
T35406	α-MSH TFA
	α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo...
TP1245L	ACTH 4-11 acetate ACTH 4-11 acetate (67224-41-3 Free base)	Others	Others
	ACTH 4-11 acetate 是一种促肾上腺皮质激素片段，具有与 α-黑素细胞刺激素 (MSH) 相同的氨基酸序列。 ACTH 4-11 acetate 仅在高剂量时表现出微弱的 MSH 效力。
T20501	Undecylenoyl phenylalanine Undecylenoylphenylalanine,Sepiwhite msh QD,Sepiwhite msh,十一碳烯酰基苯丙氨酸	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Undecylenoyl phenylalanine (Sepiwhite msh QD) 是一种新型脱色剂，可能作为 α-黑色素细胞刺激激素拮抗剂，从而抑制黑色素生成。
TP1002L	γ-1-MSH, amide acetate (72629-65-3 free base) γ-1-MSH, amide acetate	Others	Others
	γ-1-MSH, amide acetate (72629-65-3 free base) 是 ACTH/β-内啡肽 (β-EP) 前体蛋白 N 末端区域的一种推定激素，RIA 使用抗 γ-3-MSH 抗血清对产生 ACTH 的小鼠进行了研究垂体肿瘤细胞，AtT-20/D16v。
TP1101	Nonapeptide-1 acetate salt (158563-45-2 free base) Melanostatine-5 acetate salt,Nonapeptide-1 acetate salt	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Nonapeptide-1 acetate salt (158563-45-2 free base) (Melanostatine-5 acetate salt) 是一种肽激素，是一种有效的 α-黑色素细胞刺激素 (α-MSH) 拮抗剂，IC50 为 11 nM。
TP1244L1	Adrenocorticotropic Hormone (ACTH) (1-10), human acetate Adrenocorticotropic Hormone (ACTH) (1-10), human acetate(2791-05-1 Free base)	Others	Others
	Adrenocorticotropic Hormone (ACTH) (1-10), human acetate 是促肾上腺皮质激素的一个片段。 Adrenocorticotropic Hormone (ACTH) (1-10), human acetate 仅在 100 和 1000 nM 时具有较弱的 α-MSH 效力。
TP1324	Melanotan (MT)-II 美拉诺坦 II,美拉诺坦 (MT)-II	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Melanotan (MT)-II 是一种可注射用的多肽荷尔蒙，是合成的黑皮质素受体激动剂，能够促进晒黑。
TP1898	HS024 HS 024	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	HS024 是一种选择性的MC4受体拮抗剂，可增加食物摄入，对 MC4、MC5、MC3 和 MC1 的Ki 分别为 0.29、3.29、5.45 和 18.6 nM。
T76340	(Nle4)-α-MSH
	(Nle4)-α-MSH 是一种黑素细胞刺激激素α-MSH 的合成类似物。(Nle4)-α-MSH 能够使青蛙皮肤可逆变黑，并在热碱处理后表现出延长的活性。
TP1002	γ-1-MSH, amide γ-1-Melanocyte Stimulating Hormone (MSH), amide
	Gamma-MSH (Melanocyte Stimulating Hormone), a putative hormone in the N-terminal region of the ACTH/beta- endorphin (beta-EP) precursor protein, was studied by RIA with an antiserum against gamma 3-MSH in ACTH-producing mouse pituitary tumor cells, AtT-20
T33516	Msh (5-10), cyclic Cyclic H-asp-his-phe-arg-trp-lys-NH2
	Msh (5-10), cyclic, as a synthetic peptide, can conjugate with fatty acids for enhanced potency.
T75851	γ1-MSH TFA
	γ1-MSH TFA 是黑素皮质素 MC3受体激动剂，对大鼠 MC3受体的 Ki 为 34 nM。γ1-MSH TFA 在 MC4 (Ki=1318 nM) 上表现出约 40 倍的选择性。
T33515	Msh (11-13)
	Msh (11-13) is a bioactive chemical.
TP1003	Beta-MSH (1-22) human TFA (17908-57-5 free base) Beta-MSH (1-22) human TFA,β-Melanocyte Stimulating Hormone (MSH), human TFA
	β-Melanocyte Stimulating Hormone (MSH), human (Synonyms: Beta-MSH (1-22) (human)) β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.
TP1004	β-Melanocyte Stimulating Hormone (MSH), human Beta-MSH (1-22) (human)
	Stimulating -Melanocyte Stimulating Hormone (MSH), human TFA, is a 22 peptide and is an endogenous melanocortin-4 receptor.MC4 - R) agonists.
T76642	Acetyl-ACTH (2-24) (human, bovine, rat)
	Acetyl-ACTH (2-24) (human, bovine, rat) 是原黑色素皮质素 (POMC) 肽的片段。POMC 肽，如促肾上腺皮质激素(ACTH)，是α-MSH 的前体，也是MC-1受体的激动剂。
TP1244	Adrenocorticotropic Hormone (ACTH) (1-10), human ACTH (1-10), human
	Adrenocorticotropic Hormone (ACTH) (1-10), human is a fragment of the adrenocorticotropin hormone. It exhibits a weak potency of α-melanocyte stimulating hormone (α-MSH), but only at high doses (100 and 1000 nM).
T75965	β-Melanocyte Stimulating Hormone (MSH), human TFA
	β-Melanocyte Stimulating Hormone (MSH), human TFA，为一种具有22个氨基酸残基的肽类化合物，是内源性黑皮质素-4 受体(melanocortin-4 receptor; MC4-R)的激动剂。
T76643	Acetyl-ACTH (3-24) (human, bovine, rat)
	Acetyl-ACTH (3-24) (human, bovine, rat) 是原黑色素皮质素 (POMC) 肽的片段。POMC 肽，如促肾上腺皮质激素(ACTH)，是α-MSH 的前体，也是 MC-1 受体的激动剂。
TP1532	γ-2-MSH (41-58), amide
	Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to
T75971	γ-1-Melanocyte Stimulating Hormone (MSH), amide
	γ-1-Melanocyte Stimulating Hormone (MSH), amide为含11个氨基酸的多肽，主要通过激活黑皮质素受体3 (MC3-R) 调节钠 (Na+) 平衡及血压。
T76072	CCZ01048
	CCZ01048 是一种 α-MSH 类似物，与黑素皮质素 1 受体(MC1R)具有很高的结合亲和力，Ki 值为 0.31 nM。CCZ01048 具有快速内化 B16F10 黑色素瘤细胞和高体内稳定性。CCZ01048 是恶性黑色素瘤 PET 显像的一个有前途的制剂。
T75854	[D-Trp8]-γ-MSH TFA
	[D-Trp8]-γ-MSH TFA 是一种有效的、选择性的黑皮质素3 (MC3)受体激动剂，在 CHO 细胞中，抑制 hMC3，hMC4和 hMC5的 IC50值分别为 6.7 nM，600 nM 和 340 nM。[D-Trp8]-γ-MSH TFA 显示出对多种炎症性疾病(如类风湿关节炎和结肠炎)的保护作用。
T76644	Acetyl-ACTH (4-24) (human, bovine, rat)
	Acetyl-ACTH (4-24) (human, bovine, rat) 是原黑色素皮质素 (POMC) 肽的片段。POMC 肽，如促肾上腺皮质激素(ACTH)，是α-MSH 的前体，也是 MC-1受体的激动剂。
T75850	JKC363 TFA
	JKC363 TFA为选择性MC4受体拮抗剂，MC4受体(IC50=0.5 nM)亲和力是MC3受体(44.9 nM)的90倍。JKC363 TFA能阻断α-MSH对TRH释放的刺激，显示出抗痛觉效果。
T20467	Bremelanotide PT-141,PT141,PT 141
	Bremelanotide is a synthetic peptide analog of alpha-MSH and is an agonist at melanocortin receptors including the MC3R and MC4R.
T68328	Modimelanotide
	Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin receptor agonist.
T76347	Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
	Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 是一种促黑素激素，能够激活黑素细胞。该化合物具有促进酪氨酸酶活性的功能，并在大鼠模型中显示出调节体温的效果。
T75715	Nonapeptide-1 acetate salt
	Nonapeptide-1 (Melanostatine-5) acetate salt，一种多肽类激素，是 MC1R 选择性拮抗剂 (Ki: 40 nM)。 Nonapeptide-1 acetate salt 是一种竞争性的α-MSH 拮抗剂，可有效抑制黑素细胞中 α-MSH 诱导的细胞内 cAMP 和黑素体扩散 (IC50分别为 2.5 nM 和 11 nM)。 Nonapeptide-1 acetate salt 抑制黑色素合成，可用于研究皮肤色素沉着和肾上腺类固醇生成的调节、皮肤癌。
T76303	(p-Iodo-Phe7)-ACTH (4-10)
	'(p-Iodo-Phe7)-ACTH (4-10)'为垂体前腺产生和分泌的肾上腺皮质激素(ACTH)衍生物，担任黑素皮质素(MC)受体拮抗剂角色，能够抑制α-黑素细胞刺激激素(α-MSH)引发的大鼠过度梳理行为。
T75849	Lys-γ3-MSH(human) TFA
	Lys-γ3-MSH(human) TFA是源自POMC片段C端的黑素皮质素肽，具备增强大鼠肾上腺对促肾上腺皮质激素(ACTH)的类固醇生成反应的能力。该化合物作为一种有效的脂解激活剂，其表观EC50值为3.56 nM，能够激活激素敏感脂肪酶(HSL)和紫苏脂素A，进而促进脂解。
T76072L	CCZ01048 TFA
	CCZ01048 TFA 是一种 α-MSH 类似物，与黑素皮质素1受体(MC1R)具有很高的结合亲和力，Ki 值为 0.31 nM。CCZ01048 TFA 具有快速内化 B16F10 黑色素瘤细胞和高体内稳定性。CCZ01048 TFA 是恶性黑色素瘤 PET 显像的一个有前途的制剂。

化合物

a-MSH, amide Acetate(581-05-5 free base)

Cat.No: TP2212L

Target: Melanocortin Receptor

Cat.No: T7813

Synonym: MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide

Target: Melanocortin Receptor, Adenylyl cyclase

Cat.No: TP2212

Target: Others

Cat.No: TP1097

Synonym: 美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I

Target: Others

Cat.No: T35406

ACTH 4-11 acetate

Cat.No: TP1245L

Synonym: ACTH 4-11 acetate (67224-41-3 Free base)

Target: Others

Undecylenoyl phenylalanine

Cat.No: T20501

Synonym: Undecylenoylphenylalanine,Sepiwhite msh QD,Sepiwhite msh,十一碳烯酰基苯丙氨酸

Target: Melanocortin Receptor

γ-1-MSH, amide acetate (72629-65-3 free base)

Cat.No: TP1002L

Synonym: γ-1-MSH, amide acetate

Target: Others

Nonapeptide-1 acetate salt (158563-45-2 free base)

Cat.No: TP1101

Synonym: Melanostatine-5 acetate salt,Nonapeptide-1 acetate salt

Target: Melanocortin Receptor

Adrenocorticotropic Hormone (ACTH) (1-10), human acetate

Cat.No: TP1244L1

Synonym: Adrenocorticotropic Hormone (ACTH) (1-10), human acetate(2791-05-1 Free base)

Target: Others

Melanotan (MT)-II

Cat.No: TP1324

Synonym: 美拉诺坦 II,美拉诺坦 (MT)-II

Target: Melanocortin Receptor

Cat.No: TP1898

Synonym: HS 024

Target: Melanocortin Receptor

(Nle4)-α-MSH

Cat.No: T76340

γ-1-MSH, amide

Cat.No: TP1002

Synonym: γ-1-Melanocyte Stimulating Hormone (MSH), amide

Msh (5-10), cyclic

Cat.No: T33516

Synonym: Cyclic H-asp-his-phe-arg-trp-lys-NH2

Cat.No: T75851

Cat.No: T33515

Beta-MSH (1-22) human TFA (17908-57-5 free base)

Cat.No: TP1003

Synonym: Beta-MSH (1-22) human TFA,β-Melanocyte Stimulating Hormone (MSH), human TFA

β-Melanocyte Stimulating Hormone (MSH), human

Cat.No: TP1004

Synonym: Beta-MSH (1-22) (human)

Acetyl-ACTH (2-24) (human, bovine, rat)

Cat.No: T76642

Adrenocorticotropic Hormone (ACTH) (1-10), human

Cat.No: TP1244

Synonym: ACTH (1-10), human

β-Melanocyte Stimulating Hormone (MSH), human TFA

Cat.No: T75965

Acetyl-ACTH (3-24) (human, bovine, rat)

Cat.No: T76643

γ-2-MSH (41-58), amide

Cat.No: TP1532

γ-1-Melanocyte Stimulating Hormone (MSH), amide

Cat.No: T75971

Cat.No: T76072

[D-Trp8]-γ-MSH TFA

Cat.No: T75854

Acetyl-ACTH (4-24) (human, bovine, rat)

Cat.No: T76644

Cat.No: T75850

Cat.No: T20467

Synonym: PT-141,PT141,PT 141

Cat.No: T68328

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

Cat.No: T76347

Nonapeptide-1 acetate salt

Cat.No: T75715

(p-Iodo-Phe7)-ACTH (4-10)

Cat.No: T76303

Lys-γ3-MSH(human) TFA

Cat.No: T75849

Cat.No: T76072L

Cat. No.	Product Name	Target	Signaling Pathways
TN3723	Cryptomeridiol	PAFR; Antifection	GPCR/G Protein; Microbiology/Virology
	Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM.

天然产物

Cat.No: TN3723

Target: PAFR, Antifection

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