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Search Results for " a-galactosylceramide "

16

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35450	α-GalCer analog 8 α-GalCer analog 8,α-Galactosylceramide analog 8
	α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 &#181g per animal dose, indicati...
T37872	C16 Galactosylceramide (d18:1/16:0) C16 Galactosylceramide (d18:1/16:0)
	C16 Galactosylceramide is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid .
T38184	C18:1 3'-sulfo Galactosylceramide (d18:1/18:1(9Z)) C18:1 3'-sulfo Galactosylceramide (d18:1/18:1(9Z))
	C18:1 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been found in mouse brain. It has been used as a standard for the quantification of C18:1 3'-sulfo galactosylceramide in dried blood spots from patients with metachromatic leukodystrophy (MLD) by UPLC-MS.
T38281	C22 Galactosylceramide (d18:1/22:0)
	C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.1C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer's disease.2[Matreya, LLC.]
T36858	C12 Galactosylceramide (d18:1/12:0)
	C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus.
T38183	C18 3'-sulfo Galactosylceramide (d18:1/18:0) C18 3'-sulfo Galactosylceramide (d18:1/18:0)
	C18 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. Levels of short-chain sulfatides, including C18 3'-sulfo galactosylceramide, decrease with age in mice and humans. It is increased in brain from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions. Plasma levels of C18 3'-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability ...
T82801	C12 NBD Galactosylceramide
	C12 NBD galactosylceramide，一种荧光染料，作为半乳糖神经酰胺的生物活性衍生物，具有标记的荧光C12硝基苯并恶二唑（C12 NBD）基团。该化合物主要用于成像研究。
T36323	C8 Galactosylceramide (d18:1/8:0) C8 Galactosylceramide (d18:1/8:0)
	C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo....
T38185	C2 3'-sulfo Galactosylceramide (d18:1/2:0) C2 3'-sulfo Galactosylceramide (d18:1/2:0)
	C2 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been used as an internal standard in the quantification of lysosulfatides in mouse brain tissue and plasma.
T37440	C2 Adamantanyl Galactosylceramide (d18:1/2:0)
	C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively.
T21260	Psychosine Sphingosine galactoside,Galactosylsphingosine,Galactosylsphingosine (d18:1)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Psychosine (Galactosylsphingosine) 是一种 PKC 抑制剂，是半乳糖脑苷脂酶 (GALC) 酶的底物，是 Krabbe 病的潜在生物标志物。Psychosine 具有很强的细胞毒性，可诱导多种细胞死亡。
T38008	KBC-007
	KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer). It induces IL-4 and IFN-γ secretion by mouse splenocytes when used at a concentration of 0.5 ng/ml and IL-2 secretion by DN32.D3 NKT hybridoma cells co-cultured with CD1d-transfected RBL cells pre-loaded with KBC-007 at a concentration of 8 ng/ml. KBC-007 (1 μg per animal) increases levels of IL-4, but not IFN-γ, to a similar degree as α-GalCer in mouse serum. KBC-007 (0.5 μg per animal) increases the sur...
T38283	Tetracosanoyl-sulfatide C24 3'-sulfo Galactosylceramide (d18:1/24:0)
	Tetracosanoyl-sulfatide is an endogenous sulfated glycolipid, which are also known as sulfatides . Tetracosanoyl-sulfatide is the major sulfatide in mature myelin in the central and peripheral nervous systems. Levels of Tetracosanoyl-sulfatide are elevated in plasma derived from patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency, leading to sulfatide accumulation. Unlike C24:1 3'-sulfo galactosylceramide, it does not induce an immune response in mo...
T74326	αGalCer-RBD
	αGalCer-RBD 是一种佐剂脂蛋白结合物。αGalCer-RBD 可诱导对 SARS-CoV-2及其变异毒株的有效免疫。αGalCer-RBD 结合物诱导 RBD 特异性、产生细胞因子的 T 细胞发育。αGalCer-RBD 有望成为一种有效的 COVID-19 疫苗候选化合物。α-Galactosylceramide (αGalCer) 是一种有效的不变自然杀伤 T 细胞 (iNKT) 激动剂。
T81295	Retrocyclin-1
	Retrocyclin-1是一种θ防御素，具有识别并结合含碳水化合物表面分子的能力，能够保护细胞抵御HIV-1感染。该化合物对胎球蛋白、gp120（Kd=35.4 nM）、CD4（Kd=31 nM）以及半乳糖神经酰胺（Kd=24.1 nM）展现出高度亲和性。
T35639	Sulfatides (bovine) (sodium salt)
	Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, wit...

化合物

α-GalCer analog 8

Cat.No: T35450

Synonym: α-GalCer analog 8,α-Galactosylceramide analog 8

C16 Galactosylceramide (d18:1/16:0)

Cat.No: T37872

Synonym: C16 Galactosylceramide (d18:1/16:0)

C18:1 3'-sulfo Galactosylceramide (d18:1/18:1(9Z))

Cat.No: T38184

Synonym: C18:1 3'-sulfo Galactosylceramide (d18:1/18:1(9Z))

C22 Galactosylceramide (d18:1/22:0)

Cat.No: T38281

C12 Galactosylceramide (d18:1/12:0)

Cat.No: T36858

C18 3'-sulfo Galactosylceramide (d18:1/18:0)

Cat.No: T38183

Synonym: C18 3'-sulfo Galactosylceramide (d18:1/18:0)

C12 NBD Galactosylceramide

Cat.No: T82801

C8 Galactosylceramide (d18:1/8:0)

Cat.No: T36323

Synonym: C8 Galactosylceramide (d18:1/8:0)

C2 3'-sulfo Galactosylceramide (d18:1/2:0)

Cat.No: T38185

Synonym: C2 3'-sulfo Galactosylceramide (d18:1/2:0)

C2 Adamantanyl Galactosylceramide (d18:1/2:0)

Cat.No: T37440

Cat.No: T21260

Synonym: Sphingosine galactoside,Galactosylsphingosine,Galactosylsphingosine (d18:1)

Target: PKC

Cat.No: T38008

Tetracosanoyl-sulfatide

Cat.No: T38283

Synonym: C24 3'-sulfo Galactosylceramide (d18:1/24:0)

Cat.No: T74326

Cat.No: T81295

Sulfatides (bovine) (sodium salt)

Cat.No: T35639

Cat. No.	Product Name	Target	Signaling Pathways
T14193	α-Galactosylceramide KRN7000,α-GalCer	Others	Others
	α-Galactosylceramide (KRN7000) 是一种具有抗肿瘤和免疫刺激作用的合成糖脂。它是一种高效的 NKT 细胞激动剂，可与 CD1d 有效结合。它与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。
T38179	C16 3'-sulfo Galactosylceramide (d18:1/16:0) C16 3'-sulfo Galactosylceramide (d18:1/16:0)	Others	Others
	C16 3'-sulfo Galactosylceramide (d18:1/16:0)是硫酸盐类糖脂的一种。C16 3'-sulfo Galactosylceramide (d18:1/16:0)是在猪脑和血浆中发现的一种比较丰富的硫化物，在小鼠的整个发育过程中会有所减少。C16 3'-sulfo Galactosylceramide (d18:1/16:0)在体外可抑制视网膜神经节细胞生长。C16 3'-sulfo Galactosylceramide (d18:1/16:0)已被用作量化大鼠小脑和多发性硬化症患者分离的白质中的硫化物的参照物。

天然产物

α-Galactosylceramide

Cat.No: T14193

Synonym: KRN7000,α-GalCer

Target: Others

C16 3'-sulfo Galactosylceramide (d18:1/16:0)

Cat.No: T38179

Synonym: C16 3'-sulfo Galactosylceramide (d18:1/16:0)

Target: Others

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