Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6090 |
Belnacasan
VX-765 |
Caspase | Apoptosis; Proteases/Proteasome |
Belnacasan (VX-765) 是一种具有口服活性的 IL 转换酶/caspase-1 抑制剂,是 VRT-043198 的口服生物活性前药,作用于外周血单核细胞,可抑制 LPS 诱导的 IL-1β 和 IL-18 释放。 | |||
T71887 |
Hydroquinone monobenzoate
|
||
Hydroquinone monobenzoate is an oxidoreductant and potential topoisomerase II inhibitor commercially used in skin whitening treatments and photography development. It may induce DNA damage. | |||
T33243 |
MC-Val-Cit-PAB-VX765
Belnacasan-conjugate,VX765-conjugate,MC-Val-Cit-PABC-VX765 |
||
MC-VAL-CIT-PAB-VX765 or MC-VAL-CIT-PABC-VX765 is a VX765 derivative that can be conjugated to antibodies, proteins, or polymers for targeted drug delivery. MC-Val- CIT -PAB is a cathepsin cleavable ADC connector, which has been widely used in the preparat | |||
T69632 |
VRT-043198
|
||
VRT-043198 是 VX-765 (Belnacasan) 的活性代谢物,是有效的、选择性的、能透过血脑屏障的caspase-1的抑制剂。VRT-043198 对caspase-1和 caspase-4 的 Ki 值分别为 0.8 nM 和 0.6 nM。 |