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4

抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T82473 Enavermotide

UCP2

Enavermotide (UCP2)是用于主动免疫(抗肿瘤)的免疫制剂。
T22708 Darglitazone

CP-86325

PPAR DNA Damage/DNA Repair; Metabolism
Darglitazone (CP-86325) 是一种噻唑烷二酮,是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢,在 II 型糖尿病中有研究价值。
T35962 MitoPBN

MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radical...
T37297 Ru360

Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2]. Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial ce...

化合物

Enavermotide
Cat.No: T82473
Synonym: UCP2
Target:
Darglitazone
Cat.No: T22708
Synonym: CP-86325
Target: PPAR
MitoPBN
Cat.No: T35962
Synonym:
Target:
Ru360
Cat.No: T37297
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T2210 Genipin

京尼平,(+)-Genipin

Others; Autophagy Autophagy; Others
Genipin ((+)-Genipin) 是衍生自黄栀果实的天然交联剂,可抑制细胞中的 UCP2 (解偶联蛋白 2)。它有蛋白质调节、抗肿瘤、抗炎症、免疫抑制、抗血栓形成和对海马神经元保护的多种生物活性,可研究 2 型糖尿病。

天然产物

Genipin
Cat.No: T2210
Synonym: 京尼平,(+)-Genipin
Target: Others, Autophagy
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